Aloe Vera (Inner Leaf Gel) per Ulcerative Colitis (UC)

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

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In sintesi

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

Key Study Findings

Review

Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Review of natural therapies for IBD

In Vitro 1.0 weeks

Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.

Dose: 272 µg/ vs: vehicle Outcome: Ulcerative colitis severity Effetto: None None

Popolazione: Mice (DSS-induced colitis model)

Controlled Clinical Trial n=36 2 weeks

Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats.

Dose: 20, 40, or 60 mg/kg b.wt. vs: Dexamethasone 1 mg/kg and normal saline Outcome: Clinical activity index, histological alterations, DNA, NO Effetto: None None

Popolazione: Adult male Wistar rats with acetic acid-induced UC

Review

Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Ulcerative colitis patients using CAM

Other

Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing …

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: None

Controlled Clinical Trial

Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats.

Dose: None vs: Control without aloe vera Outcome: Anti-inflammatory, antioxidant, wound healing Effetto: None None

Popolazione: Animal/cell wound healing models

Key Statistics

Studi

Partecipanti

↑

Positive

Grado

Referenced Papers

Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease. Review

Current pharmaceutical biotechnology 2025 1 citazioni

Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium. Other

Current issues in … 2023 3 citazioni

Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway. Other

Phytomedicine : international … 2022 22 citazioni

Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats. Other

Toxicology reports 2022 9 citazioni

Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes. Review

Turkish journal of … 2022 3 citazioni

Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier. Other

Journal of ethnopharmacology 2021 45 citazioni

Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats. Other

Evidence-based complementary and … 2021 36 citazioni

The Healing Effect of Aloe Vera Gel on Acetic Acid-Induced Ulcerative Colitis in Rat. Other

Middle East journal … 2020 26 citazioni

Protective and Therapeutic Effects of Aloe Vera Gel on Ulcerative Colitis Induced by Acetic Acid in Rats. Other

Clinical nutrition research 2020 23 citazioni

Complementary and alternative medications in the management of inflammatory bowel disease. Review

Therapeutic advances in … 2020 21 citazioni

Barbaloin Attenuates Mucosal Damage in Experimental Models of Rat Colitis by Regulating Inflammation and the AMPK Signaling Pathway. Other

Medical science monitor … 2019 14 citazioni

Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. Review

Annals of gastroenterology 2016 41 citazioni

Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. Review

Current pharmaceutical design 2016 32 citazioni

Herbal and plant therapy in patients with inflammatory bowel disease. Review

Annals of gastroenterology 2015 135 citazioni

Advances in treatment of ulcerative colitis with herbs: from bench to bedside. Review

World journal of … 2014 23 citazioni

Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Systematic Review

Alimentary pharmacology & … 2013 128 citazioni

Herbal medicine in the treatment of ulcerative colitis. Review

Saudi journal of … 2012 138 citazioni

Review article: complementary and alternative therapies for inflammatory bowel disease. Review

Alimentary pharmacology & … 2006 181 citazioni

Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. RCT

Alimentary pharmacology & … 2004 264 citazioni

Aloe vera helps ulcerative colitis. Other

Health news (Waltham, … 2004 1 citazioni

The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative … Other

BioFactors (Oxford, England) 2003 38 citazioni

Medical therapy of inflammatory bowel disease for the 21st century. Review

The European journal … 1998 62 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
ibssupport:: 100 mL twice daily for 1-3 months
constipation:: 100-300 mg aloe latex (short-term only, maximum 1-2 weeks)

Limite massimo: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Mixed	--
272 µg/	1.0 weeks	Positive	--
20, 40, or 60 mg/kg b.wt.	2 weeks	Positive	36
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
2 g	3 weeks	Positive	--

Momento migliore per l'assunzione: Before meals; aloe latex should only be used short-term for constipation

Safety & Side Effects

Effetti collaterali segnalati

⚠ Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
⚠ Electrolyte imbalance (hypokalemia) with chronic laxative use
⚠ Potential hepatotoxicity with long-term whole leaf consumption (rare)
⚠ Allergic skin reactions in sensitive individuals

Interazioni note

● Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
● Diuretics (additive potassium loss with aloe latex)
● Diabetes medications (aloe may lower blood sugar; monitor glucose)
● Stimulant laxatives (additive laxative effect; avoid combining)
● Anticoagulants (theoretical interaction due to platelet effects)

Livello di assunzione massimo tollerabile: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Aloe Vera (Inner Leaf Gel) help with Ulcerative Colitis (UC)?

Based on 1 studies with 44 participants, there is preliminary evidence that needs more research that Aloe Vera (Inner Leaf Gel) may support Ulcerative Colitis (UC) management. Our evidence grade is D (Very Early Research).

How much Aloe Vera (Inner Leaf Gel) should I take for Ulcerative Colitis (UC)?

Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Aloe Vera (Inner Leaf Gel)?

Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Ulcerative Colitis (UC)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 44 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Ulcerative Colitis (UC)

Curcumin B Omega-3 Fatty Acids (EPA/DHA) C Butyrate (Sodium/Calcium Butyrate) C Resistant Starch D

Aloe Vera (Inner Leaf Gel) per altre condizioni

Irritable Bowel Syndrome (IBS) C

Verdetto rapido

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

Evidence Strength30%

Low confidence

Analisi degli studi

RCT (1)Meta (0)Other (0)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Ulcerative Colitis (UC)

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.