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Saccharomyces boulardii untuk Antibiotic-Associated Diarrhea (AAD)

A

Multiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.

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A

Kesimpulan

Multiple meta-analyses show S. boulardii reduces AAD risk by 47-53% (RR 0.47). Most studied probiotic for AAD prevention with consistent positive results across antibiotic classes.

Key Study Findings

Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None vs: None Outcome: None Efek: None None

Populasi: Pediatric population

Review
Intestinal Dysbiosis: Exploring Definition, Associated Symptoms, and Perspectives for a Comprehensive Understanding - a Scoping …
Dose: None vs: None Outcome: None Efek: None None

Populasi: scoping review of intestinal dysbiosis definition, symptoms, and probiotic adjuvant therapy in adults and children

Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None vs: None Outcome: Clinical guideline recommendations for pediatric GI Efek: None None

Populasi: Pediatric patients with GI disorders

Observational Study n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None vs: None Outcome: Probiotic prescribing habits of Italian PCPs Efek: L. rhamnosus GG used by 91.8% None

Populasi: Italian primary care pediatricians

Randomized Controlled Trial n=564 20 weeks Double-blind
High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent …
Dose: None vs: Placebo Outcome: Quality of life Efek: None P < .001

Populasi: None

Review
Clostridioides difficile Infections: Prevention and Treatment Strategies.
Dose: None vs: None Outcome: C. difficile infection treatment outcomes Efek: None None

Populasi: Patients with C. difficile infection

Key Statistics

25

Studi

5000

Peserta

Positive

A

Peringkat

Referenced Papers

Advances in experimental … 2024 2 sitasi
Advances in experimental … 2019 17 sitasi
The American journal … 2018 46 sitasi
Journal of pediatric … 2016 233 sitasi
Digestive diseases (Basel, … 2016 37 sitasi
The Cochrane database … 2015 233 sitasi
Journal of clinical … 2015 35 sitasi
Journal of clinical … 2011 432 sitasi
Journal for specialists … 2010 22 sitasi
American journal of … 2010
European journal of … 2009 91 sitasi
Current opinion in … 2009 82 sitasi
Advances in biochemical … 2008 535 sitasi
American family physician 2008
The Journal of … 2007 265 sitasi
The American journal … 2001 648 sitasi
International journal of … 2000 181 sitasi
Clinical infectious diseases … 1998 346 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:
250-500 mg/day (equivalent to 5-10 billion CFU)
aadprevention:
500 mg/day (start with antibiotic, continue 7 days after)
cdiffprevention:
500 mg twice daily as adjunct to standard therapy
travelersdiarrhea:
250-500 mg/day starting 5 days before travel

Batas atas: Well-tolerated up to 1,000 mg/day in clinical trials

Dosis yang Diteliti dalam Penelitian

Dosis Durasi Efek N
None -- Mixed --
None -- Positive --
None -- Positive --
None -- Mixed 279
None 20 weeks Positive 564
None -- Positive --
None 1 weeks Positive 47
Various probiotic interventions -- Positive --

Waktu terbaik diminum: Can be taken with or without food; space 2 hours from antifungals

Safety & Side Effects

Efek Samping yang Dilaporkan

  • Mild gas and bloating
  • Rare: fungemia in critically ill patients with central venous catheters
  • Thirst (yeast may increase water requirements)
  • Very rare: potential environmental contamination risk in ICU settings

Interaksi yang Diketahui

  • Antifungal medications (may kill S. boulardii, reducing effectiveness)
  • Monoamine oxidase inhibitors (S. boulardii contains tyramine)
  • Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)

Asupan atas yang dapat ditoleransi: Well-tolerated up to 1,000 mg/day in clinical trials

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Saccharomyces boulardii help with Antibiotic-Associated Diarrhea (AAD)?
Based on 25 studies with 5,000 participants, there is strong evidence from multiple clinical trials that Saccharomyces boulardii may support Antibiotic-Associated Diarrhea (AAD) management. Our evidence grade is A (Strong Evidence).
How much Saccharomyces boulardii should I take for Antibiotic-Associated Diarrhea (AAD)?
Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saccharomyces boulardii?
Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saccharomyces boulardii and Antibiotic-Associated Diarrhea (AAD)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 5,000 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Antibiotic-Associated Diarrhea (AAD)

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