Lactobacillus rhamnosus GG untuk Antibiotic-Associated Diarrhea (AAD)
A Bukti Beberapa uji klinis besar secara konsisten menunjukkan manfaat yang signifikan.Meta-analyses demonstrate LGG reduces AAD incidence by 42-49%. Most effective when started within 48 hours of antibiotic initiation and continued 7 days after completion.
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A
Kesimpulan
Meta-analyses demonstrate LGG reduces AAD incidence by 42-49%. Most effective when started within 48 hours of antibiotic initiation and continued 7 days after completion.
Key Study Findings
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
vs: None
Outcome: Probiotic prescribing habits of Italian PCPs
Efek: L. rhamnosus GG used by 91.8%
None
Populasi: Italian primary care pediatricians
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
vs: None
Outcome: Clinical guideline recommendations for pediatric GI
Efek: None
None
Populasi: Pediatric patients with GI disorders
Controlled Clinical Trial
n=24
2 weeks
Protective Effect of Probiotics on Cardiac Damage in Experimental Sepsis Model Induced by Lipopolysaccharide in …
Dose: 10^9 CFU/day for 14 days
vs: LPS-only group (no probiotics)
Outcome: Cardiac damage markers (CK-MB, cTn-I, cytokines)
Efek: None
p<0.05 to <0.001
Populasi: Male Wistar albino rats with LPS-induced sepsis
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: Pediatric population
Randomized Controlled Trial
Double-blind
A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea …
Dose: Probiotics (multi-strain)
vs: Placebo
Outcome: Antibiotic-associated diarrhea incidence
Efek: None
None
Populasi: Adult patients receiving antibiotics
Review
Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review.
Dose: S. boulardii CNCM I-745
vs: Placebo or standard care
Outcome: AAD prevention and pediatric gastroenteritis
Efek: None
None
Populasi: AAD and gastroenteritis patients (review)
Key Statistics
20
Studi
4000
Peserta
↑
Positive
A
Peringkat
Referenced Papers
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 sitasi
Medicina (Kaunas, Lithuania)
2025
1 sitasi
Antibiotics (Basel, Switzerland)
2025
Boletin medico del …
2025
Cureus
2024
1 sitasi
Cureus
2023
19 sitasi
Archivos argentinos de …
2022
23 sitasi
Canadian journal of …
2022
6 sitasi
International journal of …
2020
32 sitasi
Pediatric gastroenterology, hepatology …
2020
20 sitasi
Pharmacological research
2018
132 sitasi
A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands.
Meta-Analysis
BMC gastroenterology
2018
80 sitasi
United European gastroenterology …
2018
66 sitasi
Probiotics and antimicrobial …
2018
26 sitasi
World journal of …
2017
68 sitasi
Journal of pediatric …
2016
233 sitasi
Digestive diseases (Basel, …
2016
37 sitasi
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 sitasi
Journal of clinical …
2015
35 sitasi
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 sitasi
Nutricion hospitalaria
2015
5 sitasi
Medycyna wieku rozwojowego
2012
1 sitasi
Current opinion in …
2009
82 sitasi
Advances in biochemical …
2008
535 sitasi
The Journal of …
2007
265 sitasi
The American journal …
2006
918 sitasi
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 sitasi
Inflammation
2002
37 sitasi
The American journal …
2001
648 sitasi
Inflammation
2001
101 sitasi
The Journal of …
1999
559 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 10-20 billion CFU/day
- ibssupport:
- 10 billion CFU/day for 4-8 weeks
- aadprevention:
- 10-20 billion CFU/day (start with antibiotic, continue 7 days after)
Batas atas: Generally well-tolerated up to 40 billion CFU/day in clinical trials
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Mixed | 279 |
| None | -- | Positive | -- |
| 10^9 CFU/day for 14 days | 2 weeks | Positive | 24 |
| None | -- | Mixed | -- |
| Probiotics (multi-strain) | -- | Positive | -- |
| S. boulardii CNCM I-745 | -- | Positive | -- |
| None | -- | Positive | -- |
| Twice daily | -- | Neutral | 2650 |
Waktu terbaik diminum: On an empty stomach or 30 minutes before meals for optimal survival
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
- ⚠ Rare reports of bacteremia in severely immunocompromised individuals
- ⚠ Occasional loose stools during adjustment period
- ⚠ Very rare: systemic infection in critically ill patients with central venous catheters
Interaksi yang Diketahui
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk of infection in immunocompromised patients)
- ● Antifungals (no known interaction but may affect gut flora balance)
Asupan atas yang dapat ditoleransi: Generally well-tolerated up to 40 billion CFU/day in clinical trials
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Lactobacillus rhamnosus GG help with Antibiotic-Associated Diarrhea (AAD)?
Based on 20 studies with 4,000 participants, there is strong evidence from multiple clinical trials that Lactobacillus rhamnosus GG may support Antibiotic-Associated Diarrhea (AAD) management. Our evidence grade is A (Strong Evidence).
How much Lactobacillus rhamnosus GG should I take for Antibiotic-Associated Diarrhea (AAD)?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus rhamnosus GG?
Reported side effects may include Mild gas and bloating during initial use (usually resolves in 1-2 weeks), Rare reports of bacteremia in severely immunocompromised individuals, Occasional loose stools during adjustment period, Very rare: systemic infection in critically ill patients with central venous catheters. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus rhamnosus GG and Antibiotic-Associated Diarrhea (AAD)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 20 peer-reviewed studies with 4,000 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Antibiotic-Associated Diarrhea (AAD)
Lactobacillus rhamnosus GG untuk kondisi lain
References
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