Curcumin untuk Ulcerative Colitis (UC)
BMulticenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
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B
Kesimpulan
Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
Key Study Findings
Systematic Review
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Dose: None
vs: placebo or standard therapy
Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs)
Efek: None
None
Populasi: patients with ulcerative colitis
Other
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.
Dose: None
vs: untreated colitis controls
Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, …
Efek: None
None
Populasi: UC animal model and oxidatively stressed colon cells
Review
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
Systematic Review
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Dose: None
vs: Various comparators
Outcome: Multiple health outcomes
Efek: None
None
Populasi: Human subjects across 25 meta-analyses
Review
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
In Vitro
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Dose: None
vs: DSS-induced UC mice
Outcome: UC inflammation via SphK1/NF-kB pathway
Efek: None
None
Populasi: DSS-induced UC murine model
Key Statistics
5
Studi
400
Peserta
↑
Positive
B
Peringkat
Referenced Papers
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Systematic Review
Nutrition reviews
2026
ACS nano
2025
29 sitasi
Frontiers in immunology
2025
20 sitasi
Naunyn-Schmiedeberg's archives of …
2025
14 sitasi
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Systematic Review
Frontiers in pharmacology
2025
10 sitasi
BioFactors (Oxford, England)
2025
9 sitasi
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 sitasi
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Systematic Review
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2023
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2023
18 sitasi
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2023
5 sitasi
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2022
206 sitasi
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2022
86 sitasi
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2022
68 sitasi
Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
Meta-Analysis
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2022
39 sitasi
American family physician
2022
38 sitasi
Nutrients
2022
19 sitasi
Turkish journal of …
2022
3 sitasi
Advances in experimental …
2021
87 sitasi
Molecules (Basel, Switzerland)
2021
85 sitasi
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 sitasi
European journal of …
2021
40 sitasi
Complementary therapies in …
2021
30 sitasi
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 sitasi
Clinical gastroenterology and …
2020
49 sitasi
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 sitasi
Nutrients
2020
30 sitasi
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.
Meta-Analysis
Journal of gastroenterology …
2020
30 sitasi
Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis.
Meta-Analysis
Expert review of …
2020
25 sitasi
Therapeutic advances in …
2020
21 sitasi
Medicine
2020
4 sitasi
International journal of …
2019
137 sitasi
Nutrients
2019
71 sitasi
Critical reviews in …
2019
48 sitasi
Journal of medicinal …
2019
17 sitasi
Immunopharmacology and immunotoxicology
2018
96 sitasi
Gastroenterology clinics of …
2018
67 sitasi
Nutrients
2018
46 sitasi
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 sitasi
Medical principles and …
2017
45 sitasi
Acta medica Indonesiana
2017
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2017
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2017
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2016
41 sitasi
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 sitasi
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 sitasi
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2015
135 sitasi
Molecules (Basel, Switzerland)
2014
122 sitasi
World journal of …
2014
23 sitasi
The AAPS journal
2013
1866 sitasi
Alimentary pharmacology & …
2013
128 sitasi
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 sitasi
Food & function
2012
151 sitasi
Revista de gastroenterologia …
2008
2 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
Batas atas: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Varying dosages | -- | Positive | -- |
| None | -- | Positive | -- |
Waktu terbaik diminum: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
Interaksi yang Diketahui
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
Asupan atas yang dapat ditoleransi: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Curcumin help with Ulcerative Colitis (UC)?
Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Ulcerative Colitis (UC)
Curcumin untuk kondisi lain
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