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Bifidobacterium bifidum für Functional Dyspepsia

C

B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

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B. bifidum YIT 10347 showed improvement in acid-related and gas-related dyspepsia symptoms in Japanese studies. Mixed results in Western populations.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Controlled Clinical Trial
                
                
                n=54
                
                
                3.0 weeks
                
                
            

            
                [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with …
            
            

                
                Dose: 350 mg
                
                
                vs.: None
                
                
                Outcome: IBS symptom improvement
                
                
                Wirkung: None
                
                
                None
                
            

            
            
Population: Irritable bowel syndrome with diarrhea and antibiotic-associated diarr

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=100
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in …
            
            

                
                Dose: 100 mL/day fermented milk
                
                
                vs.: Placebo fermented milk
                
                
                Outcome: GI symptom scores (m-FSSG, GSRS)
                
                
                Wirkung: None
                
                
                None
                
            

            
            
Population: Healthy Japanese adults with GI discomfort

            
        

        
        

            

                
                    Other
                
                
                
                4.0 weeks
                
                
            

            
                Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms …
            
            

                
                Dose: 100 mL/day
                
                
                vs.: None
                
                
                Outcome: None
                
                
                Wirkung: None
                
                
                None
                
            

            
            
Population: men

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                
                Double-blind
                
            

            
                Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or …
            
            

                
                Dose: None
                
                
                vs.: Placebo + eradication regimen
                
                
                Outcome: H. pylori eradication rate and adverse effects
                
                
                Wirkung: None
                
                
                None
                
            

            
            
Population: Adults with H. pylori infection

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
4

        
Studien

    

    

        
500

        
Teilnehmer

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Bewertung

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Voprosy pitaniia
                        2023
                        
                    

                

                
                

                    

                        
                            Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Journal of dairy …
                        2018
                        
                        51 Zitierungen
                        
                    

                

                
                

                    

                        
                            Continuous consumption of fermented milk containing Bifidobacterium bifidum YIT 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Bioscience of microbiota, …
                        2015
                        
                        40 Zitierungen
                        
                    

                

                
                

                    

                        
                            Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        BMC gastroenterology
                        2013
                        
                        70 Zitierungen
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Übliche Dosierungen

                

                    
                    

                        
general:

                        
1-10 billion CFU/day

                    

                    
                    

                        
dyspepsiasupport:

                        
1 billion CFU/day (YIT 10347 strain)

                    

                    
                

                
                

                    Obergrenze: Well-tolerated up to 10 billion CFU/day in clinical trials
                

                
            

            

            
            

                
In der Forschung untersuchte Dosierungen

                

                    

                        
                            

                                Dosierung
                                Dauer
                                Wirkung
                                N
                            

                        
                        
                            
                            

                                350 mg
                                3.0 weeks
                                
                                    
                                    Positive
                                    
                                
                                54
                            

                            
                            

                                100 mL/day fermented milk
                                4 weeks
                                
                                    
                                    Positive
                                    
                                
                                100
                            

                            
                            

                                100 mL/day
                                4.0 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Beste Einnahmezeit: On an empty stomach or before meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Gemeldete Nebenwirkungen

                    
    
                        
                        
  • 
                            ⚠
                            Mild gas and bloating during initial use
                        
    • 
                        
                        
  • 
                            ⚠
                            Occasional abdominal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare loose stools
                        
    • 
                        
                        
  • 
                            ⚠
                            Very rare: bacteremia in immunocompromised individuals
                        
    • 
                        
                    

                

                

                
                

                    
Bekannte Wechselwirkungen

                    
    
                        
                        
  • 
                            ●
                            Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
                        
    • 
                        
                        
  • 
                            ●
                            Immunosuppressants (use with caution in immunocompromised patients)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerierbare Höchstaufnahmemenge: Well-tolerated up to 10 billion CFU/day in clinical trials
                    

                

                
            

            

                Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Bifidobacterium bifidum help with Functional Dyspepsia?
            
        
        

            Based on 4 studies with 500 participants, there is limited but promising evidence that Bifidobacterium bifidum may support Functional Dyspepsia management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Bifidobacterium bifidum should I take for Functional Dyspepsia?
            
        
        

            Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Bifidobacterium bifidum?
            
        
        

            Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Bifidobacterium bifidum and Functional Dyspepsia?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Andere Inhaltsstoffe für Functional Dyspepsia

                    

                        
                        
                            Ginger
                            B

                        
                        
                        
                            Deglycyrrhizinated Licorice (DGL)
                            C

                        
                        
                    

                

                

                
            

        

        

    


    
    












    

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