L-Glutamine لـ Crohn's Disease

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

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الخلاصة

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

Key Study Findings

Other

Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease.

Dose: None مقابل: None Outcome: Gut microbiota composition التأثير: None None

المجتمع المدروس: Crohn's disease patients

Controlled Clinical Trial

Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study.

Dose: Washed microbiota transplantation (WMT) مقابل: Pre-treatment baseline Outcome: Clinical remission and multi-omics changes التأثير: None None

المجتمع المدروس: Patients with Crohn's disease

Other

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.

Dose: None مقابل: None Outcome: Cholesterol levels التأثير: None None

المجتمع المدروس: Mouse model

Observational Study n=262

Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in …

Dose: Phenylacetylglutamine (PAGln, measured) مقابل: Healthy controls (n=126) Outcome: PAGln association with CD and colitis التأثير: None None

المجتمع المدروس: New-onset treatment-naive CD (n=136) + controls

In Vitro

Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.

Dose: Beclin1 constitutive activation (genetic) مقابل: Wild-type mice Outcome: Cytokine production in macrophage activation التأثير: None None

المجتمع المدروس: Beclin1 variant mice + AIEC infection

Review

[Regulation of inflammatory bowel disease by amino acids].

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: IBD patients

Key Statistics

الدراسات

200

المشاركون

↑

Positive

التقييم

Referenced Papers

Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease. Other

EMBO molecular medicine 2024 13 اقتباسات

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 اقتباسات

Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study. Other

World journal of … 2024

Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production. Other

Cell reports 2023 27 اقتباسات

Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Model Possibly via Platelet … Other

Journal of Crohn's … 2023 24 اقتباسات

Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn's disease. Other

JCI insight 2022 24 اقتباسات

[Regulation of inflammatory bowel disease by amino acids]. Review

Sheng wu gong … 2022 4 اقتباسات

COMPLEMENTARY AND ALTERNATIVE MEDICINE USE IN BRAZILIAN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. Other

Arquivos de gastroenterologia 2022 4 اقتباسات

Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials. Systematic Review

Clinical nutrition ESPEN 2021 39 اقتباسات

ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. Other

Gastroenterology 2019 118 اقتباسات

Spontaneous colitis in IL-10-deficient mice was ameliorated via inhibiting glutaminase1. Other

Journal of cellular … 2019 23 اقتباسات

Enteral nutritional therapy for induction of remission in Crohn's disease. Meta-Analysis

The Cochrane database … 2018 425 اقتباسات

Nutritional Interventions in the Patient with Inflammatory Bowel Disease. Review

Gastroenterology clinics of … 2018 67 اقتباسات

Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index. Other

Clinical medicine insights. … 2018 15 اقتباسات

Enteral Nutrition in the Management of Crohn's Disease: Reviewing Mechanisms of Actions and Highlighting Potential Venues for Enhancing the Efficacy. Review

Nutrition in clinical … 2018 10 اقتباسات

Dietary and enteral interventions for Crohn's disease. Review

Current opinion in … 2017 37 اقتباسات

Exploring and Enhancing the Anti-Inflammatory Properties of Polymeric Formula. Other

JPEN. Journal of … 2017 24 اقتباسات

Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue. Other

World journal of … 2017 21 اقتباسات

The Na+/Cl--Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis. Review

The AAPS journal 2017

Glutamine for induction of remission in Crohn's disease. Systematic Review

The Cochrane database … 2016 37 اقتباسات

The role of total parenteral nutrition in inflammatory bowel disease: current aspects. Review

Scandinavian journal of … 2014 56 اقتباسات

Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. RCT

Digestive diseases and … 2012 81 اقتباسات

Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence. Review

Frontline gastroenterology 2012 20 اقتباسات

Plasma citrulline concentration as a marker for disease activity in patients with Crohn's disease. Other

Journal of clinical … 2012 13 اقتباسات

Complementary, holistic, and integrative medicine: Crohn disease. Review

Pediatrics in review 2012

Plasma citrulline as surrogate marker of intestinal inflammation in pediatric and adolescent with Crohn's disease: preliminary report. Other

International journal of … 2011 12 اقتباسات

Potential for amino acids supplementation during inflammatory bowel diseases. Review

Inflammatory bowel diseases 2010 89 اقتباسات

[Impact of nutritional treatment in the evolution of inflammatory bowel disease]. Review

Nutricion hospitalaria 2010

Enteral nutrition as a primary therapy of Crohn's disease: the pediatric perspective. Review

Nutrition in clinical … 2009 36 اقتباسات

Combined glutamine and arginine decrease proinflammatory cytokine production by biopsies from Crohn's patients in association with changes in nuclear factor-kappaB … Other

The Journal of … 2008 89 اقتباسات

Enteral nutrition in adult Crohn's disease: present status and perspectives. Review

Molecular nutrition & … 2008 26 اقتباسات

Enteral nutritional therapy for induction of remission in Crohn's disease. Meta-Analysis

The Cochrane database … 2007 192 اقتباسات

Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation? Other

Digestive diseases and … 2006 73 اقتباسات

Immunonutrition. Review

Current opinion in … 2005 22 اقتباسات

The use of enteral nutrition in the management of Crohn's disease in adults. Review

JPEN. Journal of … 2005 19 اقتباسات

Glutamine metabolism in Crohn's disease: a stable isotope study. Other

Clinical nutrition (Edinburgh, … 2004 18 اقتباسات

[Environmental factors in the etiopathology of inflammatory bowel syndrome]. Review

Medycyna wieku rozwojowego 2004 1 اقتباسات

[Artificial nutrition in inflammatory bowel disease]. Review

Annali italiani di … 2004

Review article: nutrition and adult inflammatory bowel disease. Review

Alimentary pharmacology & … 2003 179 اقتباسات

Pharmacological nutrition in inflammatory bowel diseases. Other

Nutricion hospitalaria 2003

Inflammatory bowel diseases: principles of nutritional therapy. Review

Revista do Hospital … 2002 39 اقتباسات

Low serum concentrations of insulin-like growth factor-I in children with active Crohn disease: effect of enteral nutritional support and glutamine … RCT

Scandinavian journal of … 2002 28 اقتباسات

Enteral feeding. Other

Current opinion in … 2002 1 اقتباسات

Enteral feeding. Review

Current opinion in … 2002

Enteral nutritional therapy for inducing remission of Crohn's disease. Systematic Review

The Cochrane database … 2001 149 اقتباسات

Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease. RCT

Journal of pediatric … 2000 187 اقتباسات

Nutrition in inflammatory bowel disease. Review

Current opinion in … 2000 21 اقتباسات

Glutamine supplementation and intestinal permeability in Crohn's disease. RCT

JPEN. Journal of … 2000 18 اقتباسات

Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. RCT

JPEN. Journal of … 1999 129 اقتباسات

Mucosal metabolism in ulcerative colitis and Crohn's disease. Other

Diseases of the … 1998 26 اقتباسات

[Enteral nutrition in acute Crohn disease]. Review

Zeitschrift fur Gastroenterologie 1998 18 اقتباسات

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. Review

FASEB journal : … 1997 170 اقتباسات

[Chronic inflammatory bowel diseases and nutrition]. Review

Schweizerische medizinische Wochenschrift. … 1996

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 5-15 g/day
ibsdsupport:: 5 g three times daily (15 g/day total)
postexercisegut:: 0.25-0.9 g/kg before intense exercise
gutbarriersupport:: 0.5 g/kg/day (approximately 30-40 g/day for adults)

الحد الأعلى: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Positive	--
Washed microbiota transplantation (WMT)	--	Positive	--
None	--	Positive	--
Phenylacetylglutamine (PAGln, measured)	--	Negative	262
Beclin1 constitutive activation (genetic)	--	Positive	--
None	--	Mixed	--
None	--	Negative	--
None	--	Mixed	--

أفضل وقت للتناول: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Mild gastrointestinal discomfort at high doses
⚠ Headache
⚠ Dizziness at very high doses
⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

التفاعلات المعروفة

● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

الحد الأقصى المسموح به: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does L-Glutamine help with Crohn's Disease?

Based on 3 studies with 200 participants, there is limited but promising evidence that L-Glutamine may support Crohn's Disease management. Our evidence grade is C (Some Evidence).

How much L-Glutamine should I take for Crohn's Disease?

Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Glutamine?

Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Glutamine and Crohn's Disease?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Crohn's Disease

Omega-3 Fatty Acids (EPA/DHA) C Curcumin C Butyrate (Sodium/Calcium Butyrate) C

L-Glutamine لحالات أخرى

Irritable Bowel Syndrome (IBS) C Increased Intestinal Permeability (Leaky Gut) D

الخلاصة السريعة

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

Evidence Strength52%

Moderate confidence

تفصيل الدراسات

RCT (5)Meta (2)Other (0)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Crohn's Disease

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.