Bifidobacterium breve لـ Irritable Bowel Syndrome (IBS)

Q: Does Bifidobacterium breve help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is preliminary evidence that needs more research that Bifidobacterium breve may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).

Q: How much Bifidobacterium breve should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Bifidobacterium breve?

Reported side effects may include Mild gas during initial use, Occasional loose stools in infants (transient), Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Bifidobacterium breve and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Limited data from small studies. Preliminary evidence for symptom improvement.

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الخلاصة

Limited data from small studies. Preliminary evidence for symptom improvement.

Key Study Findings

Review

Compendium of Bifidobacterium-based probiotics: characteristics and therapeutic impact on human diseases.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Other n=1098 8 weeks Open-label

A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of …

Dose: None مقابل: None (single-arm open-label) Outcome: Treatment success for abdominal pain and bloating التأثير: 73% pain, 81.9% bloating success at T1 <0.001

المجتمع المدروس: IBS patients from 52 Italian gastroenterologists

Randomized Controlled Trial n=61 8 weeks Double-blind

Eight weeks of treatment with probiotic Bifidobacterium breve, Bif195 lowers fatigue scores in patients with …

Dose: None مقابل: Placebo Outcome: IBS-SSS symptom severity score change التأثير: None None

المجتمع المدروس: Patients with moderate-severe diarrhea-predominant IBS

Randomized Controlled Trial 4 weeks

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group …

Dose: 2 g مقابل: Placebo Outcome: Constipation symptoms التأثير: None P = 0.005

المجتمع المدروس: IBS patients

Review

Postbiotics: A new member in the biotics family.

Dose: None مقابل: None Outcome: Clinical applications overview التأثير: None None

المجتمع المدروس: General population (review)

In Vitro

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal …

Dose: None مقابل: None Outcome: Colitis severity التأثير: None None

المجتمع المدروس: Crohn's disease patients

Key Statistics

الدراسات

150

المشاركون

↑

Positive

التقييم

Referenced Papers

Compendium of Bifidobacterium-based probiotics: characteristics and therapeutic impact on human diseases. Review

Microbiome research reports 2025 16 اقتباسات

A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of irritable bowel syndrome in adults. Other

Beneficial microbes 2025

Eight weeks of treatment with probiotic Bifidobacterium breve, Bif195 lowers fatigue scores in patients with diarrhoea-predominant irritable bowel syndrome: results … Other

Frontiers in nutrition 2025

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro … Other

The Yale journal … 2024 5 اقتباسات

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Other

Journal of neurogastroenterology … 2024 4 اقتباسات

Postbiotics: A new member in the biotics family. Other

Archivos argentinos de … 2024 3 اقتباسات

Gut Microbiome Alterations Following Oral Serum-Derived Bovine Immunoglobulin Administration in the Management of Dysbiosis. Other

Cureus 2024 1 اقتباسات

Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data. Other

Journal of translational … 2023 30 اقتباسات

Dose-Response Efficacy and Mechanisms of Orally Administered Bifidobacterium breve CCFM683 on IMQ-Induced Psoriasis in Mice. Other

Nutrients 2023 19 اقتباسات

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: … Other

Journal of neurogastroenterology … 2022 21 اقتباسات

Immunomodulatory Effects of Bifidobacterium spp. and Use of Bifidobacterium breve and Bifidobacterium longum on Acute Diarrhea in Children. Other

Journal of microbiology … 2022 15 اقتباسات

Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome. Other

Scientific reports 2022 14 اقتباسات

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. Systematic Review

Journal of clinical … 2018 34 اقتباسات

Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a … Other

Journal of clinical … 2015 62 اقتباسات

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Meta-Analysis

Revista espanola de … 2013 102 اقتباسات

The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … RCT

Journal of clinical … 2012 207 اقتباسات

Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel … Other

PloS one 2012 31 اقتباسات

BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels? Other

Beneficial microbes 2011 89 اقتباسات

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat. Other

Neurogastroenterology and motility 2010 213 اقتباسات

Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. RCT

BMC gastroenterology 2010 91 اقتباسات

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. RCT

Alimentary pharmacology & … 2007 102 اقتباسات

Clinical studies on alleviating the symptoms of irritable bowel syndrome. RCT

Asia Pacific journal … 2006

A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. RCT

Alimentary pharmacology & … 2005 398 اقتباسات

Probiotics in the treatment of irritable bowel syndrome. RCT

Journal of clinical … 2004 205 اقتباسات

Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome … Other

Research in microbiology 2001 201 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 1-10 billion CFU/day
adultgisupport:: 5-10 billion CFU/day
neonatalsupport:: 1-5 billion CFU/day (as directed by pediatrician)

الحد الأعلى: Well-tolerated up to 10 billion CFU/day in clinical trials

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Mixed	--
None	8 weeks	Positive	1098
None	8 weeks	Neutral	61
2 g	4 weeks	Mixed	--
None	--	Positive	--
None	--	Positive	--
Serum-derived bovine immunoglobulin (SBI)	--	Positive	--
None	--	Positive	--

أفضل وقت للتناول: Before meals or on empty stomach; for infants, mix with breast milk or formula

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Mild gas during initial use
⚠ Occasional loose stools in infants (transient)
⚠ Rare abdominal discomfort
⚠ Very rare: bacteremia in immunocompromised individuals

التفاعلات المعروفة

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (use with caution in immunocompromised patients)

الحد الأقصى المسموح به: Well-tolerated up to 10 billion CFU/day in clinical trials

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Bifidobacterium breve help with Irritable Bowel Syndrome (IBS)?

Based on 2 studies with 150 participants, there is preliminary evidence that needs more research that Bifidobacterium breve may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).

How much Bifidobacterium breve should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bifidobacterium breve?

Reported side effects may include Mild gas during initial use, Occasional loose stools in infants (transient), Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bifidobacterium breve and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

الخلاصة السريعة

Limited data from small studies. Preliminary evidence for symptom improvement.

Evidence Strength30%

Low confidence

تفصيل الدراسات

RCT (6)Meta (1)Other (0)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Irritable Bowel Syndrome (IBS)

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.