Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.

Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut et al.

Other Nature medicine 2007 774 次引用

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Study Design

研究类型: Other
研究人群: None

干预措施: Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. None
对照组: None
主要结局: Lactobacillus acidophilus modulates intestinal pain and induces opioid and canna
效应方向: Mixed
偏倚风险: Moderate

Abstract

Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treatment of abdominal pain and irritable bowel syndrome.

简要概述

It is found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut—similar to the effects of morphine.

Used In Evidence Reviews

B Lactobacillus acidophilus 用于 Irritable Bowel Syndrome (IBS)

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.

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Study Design

Abstract

简要概述

Used In Evidence Reviews

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