Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.

Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut et al.

Other Nature medicine 2007 774 인용

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Study Design

연구 유형: Other
대상 집단: None

중재: Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. None
대조군: None
일차 결과: Lactobacillus acidophilus modulates intestinal pain and induces opioid and canna
효과 방향: Mixed
비뚤림 위험: Moderate

Abstract

Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treatment of abdominal pain and irritable bowel syndrome.

요약

It is found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut—similar to the effects of morphine.

Used In Evidence Reviews

B Lactobacillus acidophilus 관련 Irritable Bowel Syndrome (IBS)

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.

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Study Design

Abstract

요약

Used In Evidence Reviews

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