Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.

Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut et al.

Other Nature medicine 2007 774 Zitierungen

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Study Design

Studientyp: Other
Population: None

Intervention: Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. None
Vergleichsgruppe: None
Primärer Endpunkt: Lactobacillus acidophilus modulates intestinal pain and induces opioid and canna
Wirkungsrichtung: Mixed
Verzerrungsrisiko: Moderate

Abstract

Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treatment of abdominal pain and irritable bowel syndrome.

Zusammenfassung

It is found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut—similar to the effects of morphine.

Used In Evidence Reviews

B Lactobacillus acidophilus für Irritable Bowel Syndrome (IBS)

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.

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Study Design

Abstract

Zusammenfassung

Used In Evidence Reviews

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