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Butyrate (Sodium/Calcium Butyrate)
Butyrate (Sodium/Calcium Butyrate)

fatty_acid

别名: Sodium Butyrate, Calcium Butyrate, Butyric Acid, Tributyrin, ButyrEn

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About





            

                
Butyrate is a short-chain fatty acid (SCFA) that serves as the primary energy source for colonocytes, providing approximately 70% of their energy needs. It may help inhibit NF-kB signaling to support a healthy colonic inflammatory response, promote regulatory T cell differentiation, and enhance tight junction assembly and mucus layer thickness via HDAC inhibition. Research suggests oral butyrate supplementation may support symptom management in inflammatory bowel conditions.

            

        

        

        
        
        

            

  
How It Works





            

                
Primary energy source for colonocytes providing approximately 70% of cellular energy; inhibits NF-kB transcription factor reducing colonic inflammation; promotes regulatory T cell differentiation via HDAC inhibition; enhances tight junction assembly (claudin-1, ZO-1) and stimulates mucus layer thickness; activates GPR109A (HCAR2) anti-inflammatory signaling.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Ulcerative Colitis (UC)
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    390
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Crohn's Disease
                                    
                                
                                
                                    C

                                
                                
                                    2
                                
                                
                                    200
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Unpleasant taste/odor (butyric acid has a strong rancid butter smell)
                
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  • 
                    
                    Mild GI discomfort (nausea, bloating)
                
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  • 
                    
                    Belching with butyric acid odor
                
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  • 
                    
                    Enteric-coated formulations reduce taste issues
                
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Drug & Supplement Interactions





            
    
                
                
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                    5-ASA medications (mesalamine) — additive anti-inflammatory effect (potentially beneficial in IBD)
                
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  • 
                    
                    No significant adverse drug interactions known
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Omega-3 Fatty Acids (EPA/DHA)
                    
                
                
                
                    Medium-Chain Triglycerides (MCT Oil)
                    
                
                
            

        

        
    


    
    












    

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