Bacillus coagulans cho Irritable Bowel Syndrome (IBS)

Q: Does Bacillus coagulans help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 400 participants, there is moderate evidence from clinical studies that Bacillus coagulans may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

Q: How much Bacillus coagulans should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-2 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Bacillus coagulans?

Reported side effects may include Mild gas during initial use (generally less than other probiotics due to spore form), Occasional bloating, Rare loose stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Bacillus coagulans and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Reduces abdominal pain, bloating, and diarrhea in IBS. Spore-forming nature provides excellent stability and gastric acid survival.

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Kết luận

Reduces abdominal pain, bloating, and diarrhea in IBS. Spore-forming nature provides excellent stability and gastric acid survival.

Key Study Findings

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None so với: placebo Outcome: improvement in key IBS symptoms Hiệu quả: None None

Đối tượng nghiên cứu: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Randomized Controlled Trial n=61 4 weeks Double-blind

Effects of a Bacillus subtilis HU58 and Heyndrickxia faecalis SC208 spore-forming probiotic formula on gastrointestinal …

Dose: None so với: Placebo Outcome: Abdominal pain (NRS) and stool consistency (BSFS) Hiệu quả: None P = 0.003 (pain); P = 0.035 (s

Đối tượng nghiên cứu: Adults with diarrhoea-predominant IBS (IBS-D)

Randomized Controlled Trial n=100 12 weeks

Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, …

Dose: None so với: Control Outcome: Pain outcomes Hiệu quả: None P < .001

Đối tượng nghiên cứu: IBS patients

Meta-Analysis

Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review …

Dose: Various probiotic strains/mixtures so với: Placebo Outcome: Outcome-specific efficacy ranking in IBS Hiệu quả: None None

Đối tượng nghiên cứu: Adults with IBS (RCTs)

Randomized Controlled Trial 12 weeks Double-blind

The Efficacy and Safety of Single-Strain Probiotic Formulations Containing Bifidobacterium lactis or Bacillus coagulans in …

Dose: 20.5% so với: placebo Outcome: IBS symptom improvement Hiệu quả: None p = 0.038

Đối tượng nghiên cứu: Adults with IBS

Review

Oral microbial shift induced by probiotic Bacillus coagualans along with its clinical perspectives.

Dose: None so với: None Outcome: colitis/IBD severity Hiệu quả: None None

Đối tượng nghiên cứu: None

Key Statistics

Nghiên cứu

400

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Effects of a Bacillus subtilis HU58 and Heyndrickxia faecalis SC208 spore-forming probiotic formula on gastrointestinal health: results of a randomised, … Other

Beneficial microbes 2026

Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, placebo-controlled clinical trial. RCT

Medicine 2024 6 trích dẫn

Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Meta-Analysis

Nutrients 2023 33 trích dẫn

Oral microbial shift induced by probiotic Bacillus coagualans along with its clinical perspectives. Review

Journal of oral … 2023 12 trích dẫn

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 trích dẫn

The Efficacy and Safety of Single-Strain Probiotic Formulations Containing Bifidobacterium lactis or Bacillus coagulans in Adult Patients with Irritable Bowel … Other

Journal of clinical … 2023 9 trích dẫn

Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT … RCT

Medicine 2021 45 trích dẫn

Impact of a Gastrointestinal Stable Probiotic Supplement Bacillus coagulans LBSC on Human Gut Microbiome Modulation. Other

Journal of dietary … 2021 33 trích dẫn

Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management? RCT

European journal of … 2020 20 trích dẫn

Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel … RCT

Scientific reports 2019 65 trích dẫn

Bacillus coagulans and its applications in medicine. Review

Beneficial microbes 2019 45 trích dẫn

Bacillus coagulans and its applications in medicine. Other

Beneficial microbes 2019 29 trích dẫn

Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, … Other

Food & nutrition … 2018 162 trích dẫn

Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled … RCT

Beneficial microbes 2018 59 trích dẫn

Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled … RCT

Nutrition journal 2016 102 trích dẫn

A randomized double-blind placebo-controlled clinical trial on efficacy and safety of association of simethicone and Bacillus coagulans (Colinox®) in patients … RCT

European review for … 2014 33 trích dẫn

The efficacy of a synbiotic containing Bacillus Coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial. Other

Gastroenterology and hepatology … 2014

Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS. RCT

Postgraduate medicine 2009 144 trích dẫn

Effects of a proprietary Bacillus coagulans preparation on symptoms of diarrhea-predominant irritable bowel syndrome. RCT

Methods and findings … 2009 104 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 1-2 billion CFU/day
ibssupport:: 2 billion CFU/day (GBI-30 6086 strain)

Giới hạn trên: Well-tolerated up to 6 billion CFU/day in clinical trials

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Positive	--
None	4 weeks	Positive	61
None	12 weeks	Positive	100
Various probiotic strains/mixtures	--	Positive	--
20.5%	12 weeks	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--

Thời điểm dùng tốt nhất: With meals for optimal spore germination and colonization

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Mild gas during initial use (generally less than other probiotics due to spore form)
⚠ Occasional bloating
⚠ Rare loose stools

Tương tác đã biết

● Antibiotics (spore form is more resistant than vegetative probiotics, but spacing still recommended)
● Immunosuppressants (theoretical risk in immunocompromised patients)

Mức hấp thụ tối đa cho phép: Well-tolerated up to 6 billion CFU/day in clinical trials

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Bacillus coagulans help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 400 participants, there is moderate evidence from clinical studies that Bacillus coagulans may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Bacillus coagulans should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-2 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bacillus coagulans?

Reported side effects may include Mild gas during initial use (generally less than other probiotics due to spore form), Occasional bloating, Rare loose stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bacillus coagulans and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Irritable Bowel Syndrome (IBS)

Peppermint Oil A Psyllium Husk B Lactobacillus rhamnosus GG B Partially Hydrolyzed Guar Gum (PHGG) B Lactobacillus plantarum B Bifidobacterium longum B

Đánh giá nhanh

Reduces abdominal pain, bloating, and diarrhea in IBS. Spore-forming nature provides excellent stability and gastric acid survival.

Evidence Strength72%

High confidence

Phân tích nghiên cứu

RCT (9)Meta (1)Other (0)

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Xem tất cả thành phần cho Irritable Bowel Syndrome (IBS)

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