Curcumin therapy in inflammatory bowel disease: a pilot study.
Study Design
- Тип исследования
- Controlled Clinical Trial
- Размер выборки
- 10
- Популяция
- 5 ulcerative proctitis and 5 Crohn's disease patients
- Вмешательство
- Curcumin therapy in inflammatory bowel disease: a pilot study. Curcumin (pure preparation)
- Препарат сравнения
- None
- Первичный исход
- Clinical improvement in UC proctitis and Crohn's
- Направление эффекта
- Positive
- Риск систематической ошибки
- High
Abstract
Curcumin, a natural compound used as a food additive, has been shown to have anti-inflammatory and antioxidant properties in cell culture and animal studies. A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates. This encouraging pilot study suggests the need for double-blind placebo-controlled follow-up studies.
Кратко
All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates, which suggests the need for double-blind placebo-controlled follow-up studies.
Used In Evidence Reviews
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