Curcumin therapy in inflammatory bowel disease: a pilot study.
Study Design
- Tipo de estudio
- Controlled Clinical Trial
- Tamaño de muestra
- 10
- Población
- 5 ulcerative proctitis and 5 Crohn's disease patients
- Intervención
- Curcumin therapy in inflammatory bowel disease: a pilot study. Curcumin (pure preparation)
- Comparador
- None
- Resultado primario
- Clinical improvement in UC proctitis and Crohn's
- Dirección del efecto
- Positive
- Riesgo de sesgo
- High
Abstract
Curcumin, a natural compound used as a food additive, has been shown to have anti-inflammatory and antioxidant properties in cell culture and animal studies. A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates. This encouraging pilot study suggests the need for double-blind placebo-controlled follow-up studies.
TL;DR
All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates, which suggests the need for double-blind placebo-controlled follow-up studies.
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