Curcumin therapy in inflammatory bowel disease: a pilot study.
Study Design
- Tipo de Estudo
- Controlled Clinical Trial
- Tamanho da Amostra
- 10
- População
- 5 ulcerative proctitis and 5 Crohn's disease patients
- Intervenção
- Curcumin therapy in inflammatory bowel disease: a pilot study. Curcumin (pure preparation)
- Comparador
- None
- Desfecho Primário
- Clinical improvement in UC proctitis and Crohn's
- Direção do Efeito
- Positive
- Risco de Viés
- High
Abstract
Curcumin, a natural compound used as a food additive, has been shown to have anti-inflammatory and antioxidant properties in cell culture and animal studies. A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates. This encouraging pilot study suggests the need for double-blind placebo-controlled follow-up studies.
Resumo Rápido
All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates, which suggests the need for double-blind placebo-controlled follow-up studies.
Used In Evidence Reviews
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