Curcumin для Crohn's Disease
CLimited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
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C
Итог
Limited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
Key Study Findings
Meta-Analysis
n=2260
Comparative Efficacy of Medical Therapies in Reducing the Risk of Postoperative Recurrence in Crohn's Disease: …
Dose: None
или: placebo or other medical therapies
Outcome: endoscopic recurrence (Rutgeerts score >= i2) at 6 …
Эффект: adalimumab vs thiopurines OR 0.33 (95% CI 0.12-0.91); adalimumab vs vitamin D OR 0.07 (95% CI 0.01-0
None
Популяция: patients with Crohn's disease post-surgery from 42 studies (38 RCTs)
Meta-Analysis
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of …
Dose: Varying dosages
или: Placebo
Outcome: Clinical remission and response in UC
Эффект: None
None
Популяция: UC and CD patients (13 RCTs)
Systematic Review
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Dose: Peppermint oil, STW-5, psyllium, others
или: Standard care or placebo
Outcome: Symptom improvement in GI diseases
Эффект: None
None
Популяция: Patients with gastroenterological diseases
Review
Use of curcumin and its nanopreparations in the treatment of inflammatory bowel disease.
Dose: Curcumin nanoformulations
или: None
Outcome: IBD symptom improvement
Эффект: None
None
Популяция: IBD patients (preclinical/clinical review)
Review
Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and …
Dose: Various phytochemicals
или: None
Outcome: NF-kB regulation in IBD
Эффект: None
None
Популяция: In vitro and in vivo IBD models
Meta-Analysis
Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A …
Dose: None
или: Placebo or standard care
Outcome: Clinical/laboratory outcomes in autoimmune diseases
Эффект: None
None
Популяция: Patients with 10 types of autoimmune diseases
Key Statistics
3
Исследования
200
Участники
↔
Mixed
C
Оценка
Referenced Papers
Inflammatory bowel diseases
2026
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 цитирований
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 цитирований
World journal of …
2024
Metabolites
2023
134 цитирований
Frontiers in immunology
2022
68 цитирований
Molecules (Basel, Switzerland)
2021
85 цитирований
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 цитирований
United European gastroenterology …
2021
41 цитирований
European journal of …
2021
40 цитирований
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 цитирований
Journal of Crohn's …
2020
71 цитирований
Clinical gastroenterology and …
2020
49 цитирований
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 цитирований
Nutrients
2020
30 цитирований
Digestive and liver …
2020
14 цитирований
Medicine
2020
4 цитирований
International journal of …
2019
137 цитирований
Critical reviews in …
2019
48 цитирований
Journal of medicinal …
2019
17 цитирований
Current opinion in …
2019
5 цитирований
Gastroenterology clinics of …
2018
67 цитирований
Macromolecular bioscience
2018
13 цитирований
Gastroenterology
2017
335 цитирований
Medical principles and …
2017
45 цитирований
JPEN. Journal of …
2017
24 цитирований
Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review.
Systematic Review
Complementary therapies in …
2017
23 цитирований
The Medical clinics …
2017
9 цитирований
Ugeskrift for laeger
2017
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 цитирований
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 цитирований
Annals of gastroenterology
2015
135 цитирований
Molecules (Basel, Switzerland)
2014
122 цитирований
Experimental cell research
2014
16 цитирований
The AAPS journal
2013
1866 цитирований
Alimentary pharmacology & …
2013
128 цитирований
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 цитирований
Nature reviews. Gastroenterology …
2013
47 цитирований
Food & function
2012
151 цитирований
Journal of the …
2009
24 цитирований
Molecular nutrition & …
2008
67 цитирований
Revista de gastroenterologia …
2008
2 цитирований
Digestive diseases and …
2005
461 цитирований
Bioinformatics (Oxford, England)
2004
149 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
Верхний предел: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Positive | 2260 |
| Varying dosages | -- | Positive | -- |
| Peppermint oil, STW-5, psyllium, others | -- | Positive | -- |
| Curcumin nanoformulations | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Лучшее время приёма: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
Известные взаимодействия
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
Допустимый верхний уровень потребления: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Curcumin help with Crohn's Disease?
Based on 3 studies with 200 participants, there is limited but promising evidence that Curcumin may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Curcumin should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is mixed.
Related Evidence
Другие ингредиенты для Crohn's Disease
Curcumin для других состояний
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