Berberine для Gut Dysbiosis
DPreclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
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D
Итог
Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
Key Study Findings
Other
Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles.
Dose: None
или: Free berberine; DSS-induced UC model vs normal mice
Outcome: DAI scores, inflammatory cytokines, gut microbiota
Эффект: None
<0.01 (DAI); <0.05 (cytokines)
Популяция: DSS-induced UC mouse model (male KM mice)
Review
Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver …
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: None
Other
Oxyberberine alleviates fructose-induced hyperuricemia by modulating purine metabolism and gut microbiota.
Dose: None
или: Fructose-induced HUA control
Outcome: Serum uric acid levels
Эффект: None
None
Популяция: Fructose-induced hyperuricemia rats
Review
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: None
Other
Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment.
Dose: None
или: EVO alone; colitis mouse model
Outcome: Hepatotoxicity markers and colitis inflammation
Эффект: None
None
Популяция: C57 mice (normal and colitis models)
In Vitro
1 weeks
Phellodendron bark extract and berberine chloride suppress microbiome dysbiosis in a saliva-derived in vitro microcosm …
Dose: None
или: Untreated biofilm control
Outcome: Microbiome dysbiosis suppression in biofilm
Эффект: None
None
Популяция: Saliva-derived in vitro microcosm biofilm model with P. gingivalis
Key Statistics
2
Исследования
100
Участники
↑
Positive
D
Оценка
Referenced Papers
International journal of …
2025
15 цитирований
Colloids and surfaces. …
2025
11 цитирований
Pharmaceuticals (Basel, Switzerland)
2025
8 цитирований
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Review
Pharmaceuticals (Basel, Switzerland)
2025
8 цитирований
Inflammatory bowel diseases
2025
2 цитирований
Pharmaceutics
2025
2 цитирований
Phytomedicine : international …
2025
2 цитирований
The Journal of …
2025
1 цитирований
European journal of …
2025
Archives of oral …
2025
Frontiers in nutrition
2025
Biomedicine & pharmacotherapy …
2024
17 цитирований
Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature.
Systematic Review
International journal of …
2024
14 цитирований
Frontiers in pharmacology
2024
9 цитирований
Hepatology communications
2024
9 цитирований
Frontiers in microbiology
2024
6 цитирований
Frontiers in microbiology
2024
5 цитирований
Indian journal of …
2024
2 цитирований
Gut microbes
2023
108 цитирований
Biomedicine & pharmacotherapy …
2023
61 цитирований
International journal of …
2023
48 цитирований
Journal of ethnopharmacology
2023
29 цитирований
Frontiers in pharmacology
2023
20 цитирований
International journal of …
2023
18 цитирований
Current pharmaceutical design
2023
10 цитирований
Journal of oral …
2023
10 цитирований
Journal of neurogastroenterology …
2023
4 цитирований
Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome.
Review
Clinical and experimental …
2023
2 цитирований
Microorganisms
2022
212 цитирований
Food & function
2022
83 цитирований
Phytomedicine : international …
2022
67 цитирований
Biomaterials science
2022
34 цитирований
Microbiology spectrum
2022
25 цитирований
Brazilian journal of …
2022
12 цитирований
Pharmacological research
2021
186 цитирований
Pharmacological research
2021
147 цитирований
Acta pharmacologica Sinica
2021
63 цитирований
Frontiers in pharmacology
2021
42 цитирований
Frontiers in immunology
2021
22 цитирований
Comprehensive Physiology
2021
21 цитирований
International journal of …
2021
20 цитирований
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases.
Review
Pharmacological research
2020
65 цитирований
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.
Systematic Review
Journal of integrative …
2020
33 цитирований
Pharmacological research
2019
166 цитирований
American journal of …
2019
117 цитирований
Biomedicine & pharmacotherapy …
2019
72 цитирований
Scientific reports
2019
51 цитирований
Pharmacological research
2019
31 цитирований
Science China. Life …
2018
17 цитирований
Alternative therapies in …
2017
9 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 500-1,500 mg/day in divided doses
- siboprotocol:
- 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)
- giantimicrobial:
- 500 mg twice daily
Верхний предел: Generally well-tolerated up to 1,500 mg/day in divided doses
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | 1 weeks | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Лучшее время приёма: With meals; divide doses throughout the day (do not take full daily dose at once)
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
- ⚠ May cause uterine contractions (contraindicated in pregnancy)
- ⚠ Headache
- ⚠ Skin rash (rare)
Известные взаимодействия
- ● Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
- ● Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
- ● Anticoagulants (may have additive blood-thinning effects)
- ● Metformin (additive glucose-lowering effect; monitor closely)
- ● Macrolide antibiotics (berberine inhibits CYP3A4)
Допустимый верхний уровень потребления: Generally well-tolerated up to 1,500 mg/day in divided doses
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Berberine help with Gut Dysbiosis?
Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).
How much Berberine should I take for Gut Dysbiosis?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Berberine?
Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Berberine and Gut Dysbiosis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Gut Dysbiosis
Berberine для других состояний
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