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Butyrate (Sodium/Calcium Butyrate) para Ulcerative Colitis (UC)

C Evidências Evidência limitada de estudos de pequena dimensão, mas existem alguns sinais positivos.

Recent 90-day RCT (140 IBD participants) showed oral butyrate improved Crohn's symptoms and QoL. Earlier studies on butyrate enemas showed benefit in distal UC.

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Conclusão

Recent 90-day RCT (140 IBD participants) showed oral butyrate improved Crohn's symptoms and QoL. Earlier studies on butyrate enemas showed benefit in distal UC.

Key Study Findings

Randomized Controlled Trial n=140 Double-blind
Impact of oral butyrate on clinical and biochemical parameters in IBD: A randomized placebo-controlled study …
Dose: None vs: placebo plus conventional therapy Outcome: clinical disease activity and fecal calprotectin Efeito: None p=0.013

População: IBD patients (60 Crohn's disease, 80 ulcerative colitis)

basic science
Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.
Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo Efeito: None < 0.05
In Vitro
Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell …
Dose: None vs: UC animal and clinical samples Outcome: Intestinal inflammation via CD4+ T cell regulation Efeito: None None

População: UC murine model + UC patient samples

Randomized Controlled Trial n=36 12 weeks Double-blind
Effects of Short Chain Fatty Acid-Butyrate Supplementation on the Disease Severity, Inflammation, and Psychological Factors …
Dose: 600 mg/kg with main meal vs: Placebo (rice starch) Outcome: Mayo score, ESR, anxiety/depression (HADS) Efeito: Mayo score -2.33 vs +0.22 p<0.001 (Mayo, dep, GHQ)

População: Active ulcerative colitis patients

In Vitro
Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.
Dose: None vs: LPS-stimulated RAW264.7 cells Outcome: Macrophage polarization (M1 to M2 shift) Efeito: None None

População: RAW264.7 macrophage cell line

In Vitro
Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota.
Dose: 5 mg/mL vs: LPS-treated cell models Outcome: Intestinal barrier function and gut microbiota Efeito: None None

População: Caco-2 cells, RAW264.7 macrophages, fecal fermentation

Key Statistics

3

Estudos

390

Participantes

↑

Positive

C

Nota

Referenced Papers

Molecular medicine (Cambridge, … 2025 8 citações
Langenbeck's archives of … 2025 3 citações
Nutrients 2023 9 citações
Current pharmaceutical design 2018 108 citações
Comprehensive Physiology 2017 245 citações
Journal of AOAC … 2004
Current opinion in … 2000 28 citações
Diseases of the … 1998 26 citações
Digestive diseases and … 1997 254 citações
Bailliere's clinical gastroenterology 1997 26 citações
Diseases of the … 1995 31 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:
150-600 mg/day sodium or calcium butyrate
ibdsupport:
300-600 mg three times daily (900-1,800 mg/day)
butyrateenema:
100 mM butyrate enema for distal UC (clinical setting only)

Limite superior: No established upper limit for oral supplements; most studies use 600-4,000 mg/day

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
None -- Positive 140
Lactobacillus reuteri E9 (dose not specified) -- Positive --
None -- Positive --
600 mg/kg with main meal 12 weeks Positive 36
None -- Positive --
5 mg/mL -- Positive --
None -- Positive --
None -- Positive 212

Melhor horário: With meals; enteric-coated formulations recommended to reach the colon

Safety & Side Effects

Efeitos Colaterais Relatados

  • ⚠ Unpleasant taste/odor (butyric acid has a strong rancid butter smell)
  • ⚠ Mild GI discomfort (nausea, bloating)
  • ⚠ Belching with butyric acid odor
  • ⚠ Enteric-coated formulations reduce taste issues

Interações Conhecidas

  • ● 5-ASA medications (mesalamine) — additive anti-inflammatory effect (potentially beneficial in IBD)
  • ● No significant adverse drug interactions known

Ingestão máxima tolerável: No established upper limit for oral supplements; most studies use 600-4,000 mg/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Butyrate (Sodium/Calcium Butyrate) help with Ulcerative Colitis (UC)?
Based on 3 studies with 390 participants, there is limited but promising evidence that Butyrate (Sodium/Calcium Butyrate) may support Ulcerative Colitis (UC) management. Our evidence grade is C (Some Evidence).
How much Butyrate (Sodium/Calcium Butyrate) should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 150-600 mg/day sodium or calcium butyrate. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Butyrate (Sodium/Calcium Butyrate)?
Reported side effects may include Unpleasant taste/odor (butyric acid has a strong rancid butter smell), Mild GI discomfort (nausea, bloating), Belching with butyric acid odor, Enteric-coated formulations reduce taste issues. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Butyrate (Sodium/Calcium Butyrate) and Ulcerative Colitis (UC)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 390 total participants. The overall direction of effect is positive.

Butyrate (Sodium/Calcium Butyrate) para outras condições

References

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Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.