Berberine para Gut Dysbiosis
DPreclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
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D
Conclusão
Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
Key Study Findings
Other
Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles.
Dose: None
vs: Free berberine; DSS-induced UC model vs normal mice
Outcome: DAI scores, inflammatory cytokines, gut microbiota
Efeito: None
<0.01 (DAI); <0.05 (cytokines)
População: DSS-induced UC mouse model (male KM mice)
Review
Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver …
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: None
Other
Oxyberberine alleviates fructose-induced hyperuricemia by modulating purine metabolism and gut microbiota.
Dose: None
vs: Fructose-induced HUA control
Outcome: Serum uric acid levels
Efeito: None
None
População: Fructose-induced hyperuricemia rats
Review
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: None
Other
Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment.
Dose: None
vs: EVO alone; colitis mouse model
Outcome: Hepatotoxicity markers and colitis inflammation
Efeito: None
None
População: C57 mice (normal and colitis models)
In Vitro
1 weeks
Phellodendron bark extract and berberine chloride suppress microbiome dysbiosis in a saliva-derived in vitro microcosm …
Dose: None
vs: Untreated biofilm control
Outcome: Microbiome dysbiosis suppression in biofilm
Efeito: None
None
População: Saliva-derived in vitro microcosm biofilm model with P. gingivalis
Key Statistics
2
Estudos
100
Participantes
↑
Positive
D
Nota
Referenced Papers
International journal of …
2025
15 citações
Colloids and surfaces. …
2025
11 citações
Pharmaceuticals (Basel, Switzerland)
2025
8 citações
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Review
Pharmaceuticals (Basel, Switzerland)
2025
8 citações
Inflammatory bowel diseases
2025
2 citações
Pharmaceutics
2025
2 citações
Phytomedicine : international …
2025
2 citações
The Journal of …
2025
1 citações
European journal of …
2025
Archives of oral …
2025
Frontiers in nutrition
2025
Biomedicine & pharmacotherapy …
2024
17 citações
Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature.
Systematic Review
International journal of …
2024
14 citações
Frontiers in pharmacology
2024
9 citações
Hepatology communications
2024
9 citações
Frontiers in microbiology
2024
6 citações
Frontiers in microbiology
2024
5 citações
Indian journal of …
2024
2 citações
Gut microbes
2023
108 citações
Biomedicine & pharmacotherapy …
2023
61 citações
International journal of …
2023
48 citações
Journal of ethnopharmacology
2023
29 citações
Frontiers in pharmacology
2023
20 citações
International journal of …
2023
18 citações
Current pharmaceutical design
2023
10 citações
Journal of oral …
2023
10 citações
Journal of neurogastroenterology …
2023
4 citações
Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome.
Review
Clinical and experimental …
2023
2 citações
Microorganisms
2022
212 citações
Food & function
2022
83 citações
Phytomedicine : international …
2022
67 citações
Biomaterials science
2022
34 citações
Microbiology spectrum
2022
25 citações
Brazilian journal of …
2022
12 citações
Pharmacological research
2021
186 citações
Pharmacological research
2021
147 citações
Acta pharmacologica Sinica
2021
63 citações
Frontiers in pharmacology
2021
42 citações
Frontiers in immunology
2021
22 citações
Comprehensive Physiology
2021
21 citações
International journal of …
2021
20 citações
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases.
Review
Pharmacological research
2020
65 citações
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.
Systematic Review
Journal of integrative …
2020
33 citações
Pharmacological research
2019
166 citações
American journal of …
2019
117 citações
Biomedicine & pharmacotherapy …
2019
72 citações
Scientific reports
2019
51 citações
Pharmacological research
2019
31 citações
Science China. Life …
2018
17 citações
Alternative therapies in …
2017
9 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 500-1,500 mg/day in divided doses
- siboprotocol:
- 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)
- giantimicrobial:
- 500 mg twice daily
Limite superior: Generally well-tolerated up to 1,500 mg/day in divided doses
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | 1 weeks | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Melhor horário: With meals; divide doses throughout the day (do not take full daily dose at once)
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
- ⚠ May cause uterine contractions (contraindicated in pregnancy)
- ⚠ Headache
- ⚠ Skin rash (rare)
Interações Conhecidas
- ● Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
- ● Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
- ● Anticoagulants (may have additive blood-thinning effects)
- ● Metformin (additive glucose-lowering effect; monitor closely)
- ● Macrolide antibiotics (berberine inhibits CYP3A4)
Ingestão máxima tolerável: Generally well-tolerated up to 1,500 mg/day in divided doses
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Berberine help with Gut Dysbiosis?
Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).
How much Berberine should I take for Gut Dysbiosis?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Berberine?
Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Berberine and Gut Dysbiosis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Gut Dysbiosis
Berberine para outras condições
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.