Lactobacillus rhamnosus GG per Irritable Bowel Syndrome (IBS)

Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.

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In sintesi

Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.

Key Study Findings

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None vs: placebo Outcome: improvement in key IBS symptoms Effetto: None None

Popolazione: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Randomized Controlled Trial 3 weeks Double-blind

Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review …

Dose: None vs: Placebo Outcome: Pain outcomes Effetto: None None

Popolazione: IBS patients

Systematic Review n=3

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic …

Dose: None vs: None Outcome: Abdominal pain frequency/intensity, constipation Effetto: None None

Popolazione: Children with FAPD or functional constipation

Systematic Review

Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.

Dose: various probiotic strains vs: placebo Outcome: IBS symptom improvement in children Effetto: LGG showed benefit in some studies None

Popolazione: Children with IBS

Review

Probiotic Bacterial and Fungal Strains: Claims with Evidence.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Various populations (probiotic claims review)

Review

Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: IBD patients

Key Statistics

Studi

1200

Partecipanti

↑

Positive

Grado

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. Review

Nutrients 2024 5 citazioni

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. Systematic Review

Journal of clinical … 2018 34 citazioni

Probiotic Bacterial and Fungal Strains: Claims with Evidence. Review

Digestive diseases (Basel, … 2016 37 citazioni

Probiotics for Irritable Bowel Syndrome: Clinical Data in Children. Systematic Review

Journal of pediatric … 2016 19 citazioni

The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Systematic Review

Paediatric drugs 2015 122 citazioni

Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. Review

Nutrition in clinical … 2015 31 citazioni

Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. RCT

BMC gastroenterology 2010 91 citazioni

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. RCT

Alimentary pharmacology & … 2007 102 citazioni

Intestinal colonisation, microbiota and future probiotics? Review

Asia Pacific journal … 2006 45 citazioni

Clinical studies on alleviating the symptoms of irritable bowel syndrome. RCT

Asia Pacific journal … 2006

A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. RCT

Alimentary pharmacology & … 2005 398 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 10-20 billion CFU/day
ibssupport:: 10 billion CFU/day for 4-8 weeks
aadprevention:: 10-20 billion CFU/day (start with antibiotic, continue 7 days after)

Limite massimo: Generally well-tolerated up to 40 billion CFU/day in clinical trials

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	--
None	3 weeks	Positive	--
None	--	Mixed	3
various probiotic strains	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	26.0 weeks	Mixed	--

Momento migliore per l'assunzione: On an empty stomach or 30 minutes before meals for optimal survival

Safety & Side Effects

Effetti collaterali segnalati

⚠ Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
⚠ Rare reports of bacteremia in severely immunocompromised individuals
⚠ Occasional loose stools during adjustment period
⚠ Very rare: systemic infection in critically ill patients with central venous catheters

Interazioni note

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk of infection in immunocompromised patients)
● Antifungals (no known interaction but may affect gut flora balance)

Livello di assunzione massimo tollerabile: Generally well-tolerated up to 40 billion CFU/day in clinical trials

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Lactobacillus rhamnosus GG help with Irritable Bowel Syndrome (IBS)?

Based on 8 studies with 1,200 participants, there is moderate evidence from clinical studies that Lactobacillus rhamnosus GG may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Lactobacillus rhamnosus GG should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus rhamnosus GG?

Reported side effects may include Mild gas and bloating during initial use (usually resolves in 1-2 weeks), Rare reports of bacteremia in severely immunocompromised individuals, Occasional loose stools during adjustment period, Very rare: systemic infection in critically ill patients with central venous catheters. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus rhamnosus GG and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Irritable Bowel Syndrome (IBS)

Peppermint Oil A Psyllium Husk B Partially Hydrolyzed Guar Gum (PHGG) B Lactobacillus plantarum B Bifidobacterium longum B Galactooligosaccharides (GOS) B

Lactobacillus rhamnosus GG per altre condizioni

Antibiotic-Associated Diarrhea (AAD) A

Verdetto rapido

Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.

Evidence Strength72%

High confidence

Analisi degli studi

RCT (4)Meta (0)Other (4)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Irritable Bowel Syndrome (IBS)

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.