L-Glutamine untuk Crohn's Disease
CSmall RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.
Kesimpulan
Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.
Key Study Findings
Populasi: Crohn's disease patients
Populasi: Patients with Crohn's disease
Populasi: Mouse model
Populasi: New-onset treatment-naive CD (n=136) + controls
Populasi: Beclin1 variant mice + AIEC infection
Populasi: IBD patients
Key Statistics
3
Studi
200
Peserta
Positive
Peringkat
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
Batas atas: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Positive | -- |
| Washed microbiota transplantation (WMT) | -- | Positive | -- |
| None | -- | Positive | -- |
| Phenylacetylglutamine (PAGln, measured) | -- | Negative | 262 |
| Beclin1 constitutive activation (genetic) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | -- |
| None | -- | Mixed | -- |
Waktu terbaik diminum: Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
Interaksi yang Diketahui
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
Asupan atas yang dapat ditoleransi: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does L-Glutamine help with Crohn's Disease?
How much L-Glutamine should I take for Crohn's Disease?
Are there side effects of L-Glutamine?
How strong is the evidence for L-Glutamine and Crohn's Disease?
Related Evidence
Bahan lain untuk Crohn's Disease
L-Glutamine untuk kondisi lain
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