N-Acetyl Cysteine (NAC) के लिए Inflammatory Bowel Disease (IBD) — General

Pilot data only. Glutathione precursor may reduce oxidative stress in IBD. Requires larger clinical trials.

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निष्कर्ष

Pilot data only. Glutathione precursor may reduce oxidative stress in IBD. Requires larger clinical trials.

Key Study Findings

Review

Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: Review of nanocatalytic antioxidation in diseases

Randomized Controlled Trial 16 weeks Open-label

Exploring the role of oxidative stress and the effect of N-acetylcysteine in thiopurine-induced liver injury …

Dose: N-acetylcysteine with thiopurine बनाम: Thiopurine alone (crossover) Outcome: Liver injury markers and oxidative stress प्रभाव: None None

जनसंख्या: IBD patients with thiopurine-induced liver injury

Review

The emerging role of oxidative stress in inflammatory bowel disease.

Dose: None बनाम: None Outcome: Oxidative stress role in IBD pathophysiology प्रभाव: None None

जनसंख्या: IBD patients (Crohn's and UC)

In Vitro 4.3 weeks

Extraintestinal Manifestations in Induced Colitis: Controversial Effects of N-Acetylcysteine on Colon, Liver, and Kidney.

Dose: 150 mg/kg बनाम: None Outcome: inflammation markers प्रभाव: None None

जनसंख्या: Mice

Systematic Review 52 weeks

Vitamin D for the treatment of inflammatory bowel disease.

Dose: 400 IU/day बनाम: placebo Outcome: IBD disease activity प्रभाव: None None

जनसंख्या: Patients with IBD

Review

Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease …

Dose: None बनाम: None Outcome: Ferroptosis role in IBD pathogenesis प्रभाव: None None

जनसंख्या: IBD patients (mechanistic review)

Key Statistics

अध्ययन

प्रतिभागी

↑

Positive

ग्रेड

Referenced Papers

Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases. Review

Accounts of chemical … 2025 2 उद्धरण

The emerging role of oxidative stress in inflammatory bowel disease. Review

Frontiers in endocrinology 2024 165 उद्धरण

Exploring the role of oxidative stress and the effect of N-acetylcysteine in thiopurine-induced liver injury in inflammatory bowel disease: A … RCT

Basic & clinical … 2024

Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review). Review

International journal of … 2023 59 उद्धरण

Potential Use of Antioxidant Compounds for the Treatment of Inflammatory Bowel Disease. Review

Pharmaceuticals (Basel, Switzerland) 2023 18 उद्धरण

Extraintestinal Manifestations in Induced Colitis: Controversial Effects of N-Acetylcysteine on Colon, Liver, and Kidney. Other

Oxidative medicine and … 2023 11 उद्धरण

Vitamin D for the treatment of inflammatory bowel disease. Systematic Review

The Cochrane database … 2023 1 उद्धरण

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy. Other

Journal of nanobiotechnology 2022 206 उद्धरण

High-fructose corn syrup promotes proinflammatory Macrophage activation via ROS-mediated NF-κB signaling and exacerbates colitis in mice. Other

International immunopharmacology 2022 21 उद्धरण

Moronic acid improves intestinal inflammation in mice with chronic colitis by inhibiting intestinal macrophage polarization. Other

Journal of biochemical … 2022 5 उद्धरण

Vitamin D supplementation in inflammatory bowel disease: a narrative review. Review

Medwave 2022 4 उद्धरण

Diet supporting therapy for inflammatory bowel diseases. Review

European journal of … 2021 40 उद्धरण

Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress and Intestinal Inflammation. Other

Journal of inflammation … 2021 34 उद्धरण

Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis. Other

Journal of Crohn's … 2018 91 उद्धरण

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis. Other

Redox biology 2017 34 उद्धरण

Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease. Other

Digestion 2016 522 उद्धरण

Role of oxidative stress mediated by glutathione-s-transferase in thiopurines' toxic effects. Other

Chemical research in … 2015 13 उद्धरण

N-acetylcysteine expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic acid-induced colitis in rats. Other

Scandinavian journal of … 2013 65 उद्धरण

Omega-3 fatty acids and inflammatory bowel diseases - a systematic review. Systematic Review

The British journal … 2012 145 उद्धरण

Impact of environmental and dietary factors on the course of inflammatory bowel disease. Review

World journal of … 2012 113 उद्धरण

Chios mastic, a natural supplement for zinc to enhance male sexuality and prostate function. Other

Pharmaceutical biology 2010 16 उद्धरण

Effect of N-acetylcysteine on the murine model of colitis induced by dextran sodium sulfate through up-regulating PON1 activity. Other

Digestive diseases and … 2009 49 उद्धरण

Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Other

Molecular and cellular … 2007 95 उद्धरण

Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. Other

Journal of agricultural … 2007 44 उद्धरण

Beneficial effects of N-acetylcysteine on acetic acid-induced colitis in rats. Other

The Tohoku journal … 2005 114 उद्धरण

Effects of N-acetylcysteine treatment on oxidative stress in acetic acid-induced experimental colitis in rats. Other

The Journal of … 2005 63 उद्धरण

Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells. Other

Journal of leukocyte … 2002

Replenishment of glutathione levels improves mucosal function in experimental acute colitis. Other

Laboratory investigation; a … 2000 116 उद्धरण

Role of free radicals and poly(ADP-ribose) synthetase in intestinal tight junction permeability. Other

Molecular medicine (Cambridge, … 2000

Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal … Other

Alimentary pharmacology & … 1999 57 उद्धरण

Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis. Other

Gut 1996 297 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

general:: 600-1,200 mg/day in divided doses
hpyloriadjunct:: 600 mg twice daily alongside standard triple therapy
antioxidantsupport:: 600-900 mg/day

अधिकतम सीमा: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
None	--	Mixed	--
N-acetylcysteine with thiopurine	16 weeks	Positive	--
None	--	Positive	--
150 mg/kg	4.3 weeks	Positive	--
400 IU/day	52 weeks	Mixed	--
None	--	Neutral	--
Various antioxidant compounds	--	Positive	--
None	--	Mixed	--

सेवन का सर्वोत्तम समय: With or without food; divide doses throughout the day

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Nausea and vomiting (most common, especially at higher doses)
⚠ Diarrhea
⚠ Unpleasant sulfur taste/odor
⚠ Headache

ज्ञात अंतःक्रियाएँ

● Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
● Activated charcoal (may reduce NAC absorption)
● Anticoagulants (NAC may have mild antiplatelet effects)
● ACE inhibitors (additive hypotensive effect with nitroglycerin combination)

सहनीय अधिकतम सेवन: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does N-Acetyl Cysteine (NAC) help with Inflammatory Bowel Disease (IBD) — General?

Based on 1 studies with 30 participants, there is preliminary evidence that needs more research that N-Acetyl Cysteine (NAC) may support Inflammatory Bowel Disease (IBD) — General management. Our evidence grade is D (Very Early Research).

How much N-Acetyl Cysteine (NAC) should I take for Inflammatory Bowel Disease (IBD) — General?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetyl Cysteine (NAC)?

Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetyl Cysteine (NAC) and Inflammatory Bowel Disease (IBD) — General?

We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 30 total participants. The overall direction of effect is positive.

Related Evidence

इसके लिए अन्य सामग्री Inflammatory Bowel Disease (IBD) — General

Vitamin D B

N-Acetyl Cysteine (NAC) अन्य स्वास्थ्य स्थितियों के लिए

Helicobacter pylori Infection C

संक्षिप्त निष्कर्ष

Pilot data only. Glutathione precursor may reduce oxidative stress in IBD. Requires larger clinical trials.

Evidence Strength30%

Low confidence

अध्ययन विश्लेषण

RCT (1)Meta (0)Other (0)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें Inflammatory Bowel Disease (IBD) — General

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।