N-Acetyl Cysteine (NAC) untuk Inflammatory Bowel Disease (IBD) — General
D Penelitian Hanya penelitian awal yang ada (studi laboratorium, laporan kasus).Pilot data only. Glutathione precursor may reduce oxidative stress in IBD. Requires larger clinical trials.
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D
Kesimpulan
Pilot data only. Glutathione precursor may reduce oxidative stress in IBD. Requires larger clinical trials.
Key Study Findings
Review
Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: Review of nanocatalytic antioxidation in diseases
Randomized Controlled Trial
16 weeks
Open-label
Exploring the role of oxidative stress and the effect of N-acetylcysteine in thiopurine-induced liver injury …
Dose: N-acetylcysteine with thiopurine
vs: Thiopurine alone (crossover)
Outcome: Liver injury markers and oxidative stress
Efek: None
None
Populasi: IBD patients with thiopurine-induced liver injury
Review
The emerging role of oxidative stress in inflammatory bowel disease.
Dose: None
vs: None
Outcome: Oxidative stress role in IBD pathophysiology
Efek: None
None
Populasi: IBD patients (Crohn's and UC)
In Vitro
4.3 weeks
Extraintestinal Manifestations in Induced Colitis: Controversial Effects of N-Acetylcysteine on Colon, Liver, and Kidney.
Dose: 150 mg/kg
vs: None
Outcome: inflammation markers
Efek: None
None
Populasi: Mice
Systematic Review
52 weeks
Vitamin D for the treatment of inflammatory bowel disease.
Dose: 400 IU/day
vs: placebo
Outcome: IBD disease activity
Efek: None
None
Populasi: Patients with IBD
Review
Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease …
Dose: None
vs: None
Outcome: Ferroptosis role in IBD pathogenesis
Efek: None
None
Populasi: IBD patients (mechanistic review)
Key Statistics
1
Studi
30
Peserta
↑
Positive
D
Peringkat
Referenced Papers
Accounts of chemical …
2025
2 sitasi
Frontiers in endocrinology
2024
165 sitasi
Basic & clinical …
2024
International journal of …
2023
59 sitasi
Pharmaceuticals (Basel, Switzerland)
2023
18 sitasi
Oxidative medicine and …
2023
11 sitasi
Vitamin D for the treatment of inflammatory bowel disease.
Systematic Review
The Cochrane database …
2023
1 sitasi
Journal of nanobiotechnology
2022
206 sitasi
International immunopharmacology
2022
21 sitasi
Journal of biochemical …
2022
5 sitasi
Medwave
2022
4 sitasi
European journal of …
2021
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Journal of inflammation …
2021
34 sitasi
Journal of Crohn's …
2018
91 sitasi
Redox biology
2017
34 sitasi
Digestion
2016
522 sitasi
Chemical research in …
2015
13 sitasi
Scandinavian journal of …
2013
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The British journal …
2012
145 sitasi
World journal of …
2012
113 sitasi
Pharmaceutical biology
2010
16 sitasi
Digestive diseases and …
2009
49 sitasi
Molecular and cellular …
2007
95 sitasi
Journal of agricultural …
2007
44 sitasi
The Tohoku journal …
2005
114 sitasi
The Journal of …
2005
63 sitasi
Journal of leukocyte …
2002
Laboratory investigation; a …
2000
116 sitasi
Role of free radicals and poly(ADP-ribose) synthetase in intestinal tight junction permeability.
Other
Molecular medicine (Cambridge, …
2000
Alimentary pharmacology & …
1999
57 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 600-1,200 mg/day in divided doses
- hpyloriadjunct:
- 600 mg twice daily alongside standard triple therapy
- antioxidantsupport:
- 600-900 mg/day
Batas atas: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| N-acetylcysteine with thiopurine | 16 weeks | Positive | -- |
| None | -- | Positive | -- |
| 150 mg/kg | 4.3 weeks | Positive | -- |
| 400 IU/day | 52 weeks | Mixed | -- |
| None | -- | Neutral | -- |
| Various antioxidant compounds | -- | Positive | -- |
| None | -- | Mixed | -- |
Waktu terbaik diminum: With or without food; divide doses throughout the day
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Nausea and vomiting (most common, especially at higher doses)
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/odor
- ⚠ Headache
Interaksi yang Diketahui
- ● Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
- ● Activated charcoal (may reduce NAC absorption)
- ● Anticoagulants (NAC may have mild antiplatelet effects)
- ● ACE inhibitors (additive hypotensive effect with nitroglycerin combination)
Asupan atas yang dapat ditoleransi: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does N-Acetyl Cysteine (NAC) help with Inflammatory Bowel Disease (IBD) — General?
Based on 1 studies with 30 participants, there is preliminary evidence that needs more research that N-Acetyl Cysteine (NAC) may support Inflammatory Bowel Disease (IBD) — General management. Our evidence grade is D (Very Early Research).
How much N-Acetyl Cysteine (NAC) should I take for Inflammatory Bowel Disease (IBD) — General?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine (NAC)?
Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine (NAC) and Inflammatory Bowel Disease (IBD) — General?
We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 30 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Inflammatory Bowel Disease (IBD) — General
N-Acetyl Cysteine (NAC) untuk kondisi lain
References
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