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N-Acetyl Cysteine (NAC) pour Helicobacter pylori Infection

C

NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

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En conclusion

NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

Key Study Findings

In Vitro
Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity.
Dose: MIC 11 μg/mL vs: None Outcome: anti-Helicobacter pylori activity Effet: None None

Population: None

Other
Correction to "N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter …
Dose: None vs: None Outcome: None Effet: None None

Population: Published erratum (correction notice)

Other
Liposomal Drug Delivery against Helicobacter pylori Using Furazolidone and N-Acetyl Cysteine in Augmented Therapy.
Dose: None vs: None Outcome: Cancer outcomes Effet: None None

Population: Cancer patients

In Vitro
Helicobacter pylori infection selectively attenuates endothelial function in male mice via exosomes-mediated ROS production.
Dose: None vs: None Outcome: choline levels/cognition Effet: None None

Population: Mice

Key Statistics

3

Études

250

Participants

Positive

C

Note

Referenced Papers

The Cochrane database … 2019 21 citations
World journal of … 2015 21 citations
American family physician 2009
Digestive diseases and … 2004 53 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:
600-1,200 mg/day in divided doses
hpyloriadjunct:
600 mg twice daily alongside standard triple therapy
antioxidantsupport:
600-900 mg/day

Limite supérieure : Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

Posologies étudiées dans la recherche

Posologie Durée Effet N
MIC 11 μg/mL -- Positive --
None -- Mixed --
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Mixed --
None -- Negative --
None -- Positive --

Moment optimal de prise : With or without food; divide doses throughout the day

Safety & Side Effects

Effets indésirables signalés

  • Nausea and vomiting (most common, especially at higher doses)
  • Diarrhea
  • Unpleasant sulfur taste/odor
  • Headache

Interactions connues

  • Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
  • Activated charcoal (may reduce NAC absorption)
  • Anticoagulants (NAC may have mild antiplatelet effects)
  • ACE inhibitors (additive hypotensive effect with nitroglycerin combination)

Apport maximal tolérable : Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does N-Acetyl Cysteine (NAC) help with Helicobacter pylori Infection?
Based on 3 studies with 250 participants, there is limited but promising evidence that N-Acetyl Cysteine (NAC) may support Helicobacter pylori Infection management. Our evidence grade is C (Some Evidence).
How much N-Acetyl Cysteine (NAC) should I take for Helicobacter pylori Infection?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine (NAC)?
Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine (NAC) and Helicobacter pylori Infection?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Related Evidence

Autres ingrédients pour Helicobacter pylori Infection

N-Acetyl Cysteine (NAC) pour d'autres pathologies

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.