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N-Acetyl Cysteine (NAC) für Helicobacter pylori Infection

C

NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

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C

Fazit

NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

Key Study Findings

In Vitro
Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity.
Dose: MIC 11 μg/mL vs.: None Outcome: anti-Helicobacter pylori activity Wirkung: None None

Population: None

Other
Correction to "N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter …
Dose: None vs.: None Outcome: None Wirkung: None None

Population: Published erratum (correction notice)

Other
Liposomal Drug Delivery against Helicobacter pylori Using Furazolidone and N-Acetyl Cysteine in Augmented Therapy.
Dose: None vs.: None Outcome: Cancer outcomes Wirkung: None None

Population: Cancer patients

In Vitro
Helicobacter pylori infection selectively attenuates endothelial function in male mice via exosomes-mediated ROS production.
Dose: None vs.: None Outcome: choline levels/cognition Wirkung: None None

Population: Mice

Key Statistics

3

Studien

250

Teilnehmer

Positive

C

Bewertung

Referenced Papers

The Cochrane database … 2019 21 Zitierungen
World journal of … 2015 21 Zitierungen
Probiotics and antimicrobial … 2010 9 Zitierungen
American family physician 2009
Digestive diseases and … 2004 53 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
600-1,200 mg/day in divided doses
hpyloriadjunct:
600 mg twice daily alongside standard triple therapy
antioxidantsupport:
600-900 mg/day

Obergrenze: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
MIC 11 μg/mL -- Positive --
None -- Mixed --
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Mixed --
None -- Negative --
None -- Positive --

Beste Einnahmezeit: With or without food; divide doses throughout the day

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Nausea and vomiting (most common, especially at higher doses)
  • Diarrhea
  • Unpleasant sulfur taste/odor
  • Headache

Bekannte Wechselwirkungen

  • Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
  • Activated charcoal (may reduce NAC absorption)
  • Anticoagulants (NAC may have mild antiplatelet effects)
  • ACE inhibitors (additive hypotensive effect with nitroglycerin combination)

Tolerierbare Höchstaufnahmemenge: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does N-Acetyl Cysteine (NAC) help with Helicobacter pylori Infection?
Based on 3 studies with 250 participants, there is limited but promising evidence that N-Acetyl Cysteine (NAC) may support Helicobacter pylori Infection management. Our evidence grade is C (Some Evidence).
How much N-Acetyl Cysteine (NAC) should I take for Helicobacter pylori Infection?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine (NAC)?
Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine (NAC) and Helicobacter pylori Infection?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Related Evidence

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N-Acetyl Cysteine (NAC) für andere Beschwerden

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