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N-Acetyl Cysteine (NAC) لـ Helicobacter pylori Infection

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NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

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الخلاصة

NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

Key Study Findings

In Vitro
Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity.
Dose: MIC 11 μg/mL مقابل: None Outcome: anti-Helicobacter pylori activity التأثير: None None

المجتمع المدروس: None

Other
Correction to "N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter …
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Published erratum (correction notice)

Review
Posttranslational modifications in Helicobacter pylori-associated gastric pathogenesis: Bridging inflammation and carcinogenesis.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Other
Liposomal Drug Delivery against Helicobacter pylori Using Furazolidone and N-Acetyl Cysteine in Augmented Therapy.
Dose: None مقابل: None Outcome: Cancer outcomes التأثير: None None

المجتمع المدروس: Cancer patients

In Vitro
Helicobacter pylori infection selectively attenuates endothelial function in male mice via exosomes-mediated ROS production.
Dose: None مقابل: None Outcome: choline levels/cognition التأثير: None None

المجتمع المدروس: Mice

Other
α-Lipoic Acid Inhibits Apoptosis by Suppressing the Loss of Ku Proteins in Helicobacter pylori-Infected Human …
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Key Statistics

3

الدراسات

250

المشاركون

Positive

C

التقييم

Referenced Papers

The Cochrane database … 2019 21 اقتباسات
World journal of … 2015 21 اقتباسات
Journal of clinical … 2011 34 اقتباسات
Probiotics and antimicrobial … 2010 9 اقتباسات
American family physician 2009
Digestive diseases and … 2004 53 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:
600-1,200 mg/day in divided doses
hpyloriadjunct:
600 mg twice daily alongside standard triple therapy
antioxidantsupport:
600-900 mg/day

الحد الأعلى: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

الجرعات المدروسة في الأبحاث

الجرعة المدة التأثير ن
MIC 11 μg/mL -- Positive --
None -- Mixed --
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Mixed --
None -- Negative --
None -- Positive --

أفضل وقت للتناول: With or without food; divide doses throughout the day

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

  • Nausea and vomiting (most common, especially at higher doses)
  • Diarrhea
  • Unpleasant sulfur taste/odor
  • Headache

التفاعلات المعروفة

  • Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
  • Activated charcoal (may reduce NAC absorption)
  • Anticoagulants (NAC may have mild antiplatelet effects)
  • ACE inhibitors (additive hypotensive effect with nitroglycerin combination)

الحد الأقصى المسموح به: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does N-Acetyl Cysteine (NAC) help with Helicobacter pylori Infection?
Based on 3 studies with 250 participants, there is limited but promising evidence that N-Acetyl Cysteine (NAC) may support Helicobacter pylori Infection management. Our evidence grade is C (Some Evidence).
How much N-Acetyl Cysteine (NAC) should I take for Helicobacter pylori Infection?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine (NAC)?
Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine (NAC) and Helicobacter pylori Infection?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Helicobacter pylori Infection

N-Acetyl Cysteine (NAC) لحالات أخرى

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.