Curcumin لـ Crohn's Disease
CLimited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
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C
الخلاصة
Limited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
Key Study Findings
Meta-Analysis
n=2260
Comparative Efficacy of Medical Therapies in Reducing the Risk of Postoperative Recurrence in Crohn's Disease: …
Dose: None
مقابل: placebo or other medical therapies
Outcome: endoscopic recurrence (Rutgeerts score >= i2) at 6 …
التأثير: adalimumab vs thiopurines OR 0.33 (95% CI 0.12-0.91); adalimumab vs vitamin D OR 0.07 (95% CI 0.01-0
None
المجتمع المدروس: patients with Crohn's disease post-surgery from 42 studies (38 RCTs)
Meta-Analysis
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of …
Dose: Varying dosages
مقابل: Placebo
Outcome: Clinical remission and response in UC
التأثير: None
None
المجتمع المدروس: UC and CD patients (13 RCTs)
Systematic Review
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Dose: Peppermint oil, STW-5, psyllium, others
مقابل: Standard care or placebo
Outcome: Symptom improvement in GI diseases
التأثير: None
None
المجتمع المدروس: Patients with gastroenterological diseases
Review
Use of curcumin and its nanopreparations in the treatment of inflammatory bowel disease.
Dose: Curcumin nanoformulations
مقابل: None
Outcome: IBD symptom improvement
التأثير: None
None
المجتمع المدروس: IBD patients (preclinical/clinical review)
Review
Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and …
Dose: Various phytochemicals
مقابل: None
Outcome: NF-kB regulation in IBD
التأثير: None
None
المجتمع المدروس: In vitro and in vivo IBD models
Meta-Analysis
Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A …
Dose: None
مقابل: Placebo or standard care
Outcome: Clinical/laboratory outcomes in autoimmune diseases
التأثير: None
None
المجتمع المدروس: Patients with 10 types of autoimmune diseases
Key Statistics
3
الدراسات
200
المشاركون
↔
Mixed
C
التقييم
Referenced Papers
Inflammatory bowel diseases
2026
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 اقتباسات
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 اقتباسات
World journal of …
2024
Metabolites
2023
134 اقتباسات
Frontiers in immunology
2022
68 اقتباسات
Molecules (Basel, Switzerland)
2021
85 اقتباسات
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 اقتباسات
United European gastroenterology …
2021
41 اقتباسات
European journal of …
2021
40 اقتباسات
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 اقتباسات
Journal of Crohn's …
2020
71 اقتباسات
Clinical gastroenterology and …
2020
49 اقتباسات
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 اقتباسات
Nutrients
2020
30 اقتباسات
Digestive and liver …
2020
14 اقتباسات
Medicine
2020
4 اقتباسات
International journal of …
2019
137 اقتباسات
Critical reviews in …
2019
48 اقتباسات
Journal of medicinal …
2019
17 اقتباسات
Current opinion in …
2019
5 اقتباسات
Gastroenterology clinics of …
2018
67 اقتباسات
Macromolecular bioscience
2018
13 اقتباسات
Gastroenterology
2017
335 اقتباسات
Medical principles and …
2017
45 اقتباسات
JPEN. Journal of …
2017
24 اقتباسات
Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review.
Systematic Review
Complementary therapies in …
2017
23 اقتباسات
The Medical clinics …
2017
9 اقتباسات
Ugeskrift for laeger
2017
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 اقتباسات
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 اقتباسات
Annals of gastroenterology
2015
135 اقتباسات
Molecules (Basel, Switzerland)
2014
122 اقتباسات
Experimental cell research
2014
16 اقتباسات
The AAPS journal
2013
1866 اقتباسات
Alimentary pharmacology & …
2013
128 اقتباسات
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 اقتباسات
Nature reviews. Gastroenterology …
2013
47 اقتباسات
Food & function
2012
151 اقتباسات
Journal of the …
2009
24 اقتباسات
Molecular nutrition & …
2008
67 اقتباسات
Revista de gastroenterologia …
2008
2 اقتباسات
Digestive diseases and …
2005
461 اقتباسات
Bioinformatics (Oxford, England)
2004
149 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
الحد الأعلى: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | 2260 |
| Varying dosages | -- | Positive | -- |
| Peppermint oil, STW-5, psyllium, others | -- | Positive | -- |
| Curcumin nanoformulations | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
أفضل وقت للتناول: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
التفاعلات المعروفة
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
الحد الأقصى المسموح به: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Curcumin help with Crohn's Disease?
Based on 3 studies with 200 participants, there is limited but promising evidence that Curcumin may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Curcumin should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is mixed.
Related Evidence
مكونات أخرى لـ Crohn's Disease
Curcumin لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.