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Aloe Vera (Inner Leaf Gel) لـ Ulcerative Colitis (UC)

D

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

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D

الخلاصة

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

Key Study Findings

Review
Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Review of natural therapies for IBD

In Vitro 1.0 weeks
Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Dose: 272 µg/ مقابل: vehicle Outcome: Ulcerative colitis severity التأثير: None None

المجتمع المدروس: Mice (DSS-induced colitis model)

Controlled Clinical Trial n=36 2 weeks
Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats.
Dose: 20, 40, or 60 mg/kg b.wt. مقابل: Dexamethasone 1 mg/kg and normal saline Outcome: Clinical activity index, histological alterations, DNA, NO التأثير: None None

المجتمع المدروس: Adult male Wistar rats with acetic acid-induced UC

Review
Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Ulcerative colitis patients using CAM

Other
Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing …
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Controlled Clinical Trial
Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats.
Dose: None مقابل: Control without aloe vera Outcome: Anti-inflammatory, antioxidant, wound healing التأثير: None None

المجتمع المدروس: Animal/cell wound healing models

Key Statistics

1

الدراسات

44

المشاركون

Positive

D

التقييم

Referenced Papers

Current pharmaceutical biotechnology 2025 1 اقتباسات
Annals of gastroenterology 2015 135 اقتباسات
Alimentary pharmacology & … 2013 128 اقتباسات
Saudi journal of … 2012 138 اقتباسات
Alimentary pharmacology & … 2006 181 اقتباسات
Health news (Waltham, … 2004 1 اقتباسات
The European journal … 1998 62 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:
100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
ibssupport:
100 mL twice daily for 1-3 months
constipation:
100-300 mg aloe latex (short-term only, maximum 1-2 weeks)

الحد الأعلى: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

الجرعات المدروسة في الأبحاث

الجرعة المدة التأثير ن
None -- Mixed --
272 µg/ 1.0 weeks Positive --
20, 40, or 60 mg/kg b.wt. 2 weeks Positive 36
None -- Mixed --
None -- Mixed --
None -- Positive --
None -- Positive --
2 g 3 weeks Positive --

أفضل وقت للتناول: Before meals; aloe latex should only be used short-term for constipation

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

  • Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
  • Electrolyte imbalance (hypokalemia) with chronic laxative use
  • Potential hepatotoxicity with long-term whole leaf consumption (rare)
  • Allergic skin reactions in sensitive individuals

التفاعلات المعروفة

  • Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
  • Diuretics (additive potassium loss with aloe latex)
  • Diabetes medications (aloe may lower blood sugar; monitor glucose)
  • Stimulant laxatives (additive laxative effect; avoid combining)
  • Anticoagulants (theoretical interaction due to platelet effects)

الحد الأقصى المسموح به: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Aloe Vera (Inner Leaf Gel) help with Ulcerative Colitis (UC)?
Based on 1 studies with 44 participants, there is preliminary evidence that needs more research that Aloe Vera (Inner Leaf Gel) may support Ulcerative Colitis (UC) management. Our evidence grade is D (Very Early Research).
How much Aloe Vera (Inner Leaf Gel) should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aloe Vera (Inner Leaf Gel)?
Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Ulcerative Colitis (UC)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 44 total participants. The overall direction of effect is positive.

Related Evidence

Aloe Vera (Inner Leaf Gel) لحالات أخرى

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.