Inulin 用于 Gut Dysbiosis

Increases Bifidobacterium counts (1-2 log). Whether this diversity improvement translates to clinical outcomes is unclear.

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结论

Increases Bifidobacterium counts (1-2 log). Whether this diversity improvement translates to clinical outcomes is unclear.

Key Study Findings

Review

Prebiotics and Gut Health: Mechanisms, Clinical Evidence, and Future Directions.

Dose: None vs: None Outcome: gut health outcomes including microbiota modulation and SCFA … 效果: None None

研究人群: healthy individuals, children, elderly, and those with constipation, metabolic syndrome, or dysbiosis

Review

Interplay of probiotics, prebiotics, synbiotics and postbiotics: a review of their therapeutic potential for gastrointestinal …

Dose: None vs: None Outcome: None 效果: None None

研究人群: review of prebiotics, probiotics, synbiotics, postbiotics for gastrointestinal inflammation

In Vitro

Orchestrating Gut Disorders by Oral Delivery of a Living-Synthetic Hybrid Hydrogel.

Dose: None vs: UC murine model Outcome: UC pathological microenvironment amelioration 效果: None None

研究人群: UC murine model

In Vitro 2 weeks

Inulin alleviates chronic ketamine-induced impairments in memory and prepulse inhibition by regulating the gut microbiota, …

Dose: None vs: Chronic ketamine (14 days) mouse model Outcome: Memory and PPI improvement 效果: None None

研究人群: Chronic ketamine-exposed mice

In Vitro

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis.

Dose: None vs: High-fructose diet mice Outcome: Hepatic steatosis and insulin resistance reversal 效果: None None

研究人群: Male mice on high-fructose diet

Review

Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Key Statistics

研究数量

200

受试者

↑

Positive

等级

Referenced Papers

Prebiotics and Gut Health: Mechanisms, Clinical Evidence, and Future Directions. Review

Nutrients 2026 1 次引用

Interplay of probiotics, prebiotics, synbiotics and postbiotics: a review of their therapeutic potential for gastrointestinal inflammation. Review

Food research international … 2026

Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review. Review

Children (Basel, Switzerland) 2025 18 次引用

Orchestrating Gut Disorders by Oral Delivery of a Living-Synthetic Hybrid Hydrogel. Other

ACS nano 2025 10 次引用

Inulin alleviates chronic ketamine-induced impairments in memory and prepulse inhibition by regulating the gut microbiota, inflammation, and kynurenine pathway. Other

International journal of … 2025 8 次引用

Effects of Chlorpyrifos on gut dysbiosis and barriers integrity in women with a focus on pregnancy and prebiotic intervention: Insights … Other

Environmental pollution (Barking, … 2025 6 次引用

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis. Other

Nature metabolism 2025 6 次引用

Indole lactic acid derived from Akkermansia muciniphila activates the aryl hydrocarbon receptor to inhibit ferroptosis in ischemic stroke. Other

Free radical biology … 2025 5 次引用

Comprehensive Management of Ulcerative Colitis and its Associated Intra-Extra Intestinal Complications with a Multifunctional Inulin Hydrogel Complex. Other

Small (Weinheim an … 2025 4 次引用

Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer's disease in the cortex of APP/PS1 mice. Other

Frontiers in pharmacology 2025 4 次引用

Prebiotic supplementation in patients with type 1 diabetes: study protocol for a randomised controlled trial in Canada. Other

BMJ open 2025 2 次引用

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention. RCT

Clinical nutrition ESPEN 2025 2 次引用

Inulin supplementation modulates gut microbiota derived metabolites related to brain function in children with obesity. RCT

Scientific reports 2025 1 次引用

Amyloid-β-driven Alzheimer's disease reshapes the colonic immune system in mice. Other

Cell reports 2025 1 次引用

Inulin-induced improvements on bowel habit and gut microbiota in adults with functional constipation: findings of a randomized, double-blind, placebo-controlled study. RCT

BMC gastroenterology 2025 1 次引用

The role of traditional Chinese medicine in modulating gut microbiota to alleviating insulin resistance in polycystic ovary syndrome. Review

Frontiers in nutrition 2025

Hydrogen Therapy and Lipopolysaccharide Trapping with MgB2@Inulin Gel for Reversing Colitis and Its Associated Psychiatric Complications via the Gut-Brain Axis. Other

ACS nano 2025

Gut microbiota mediates prenatal METH exposure-induced anxiety- and depression-like behaviors by modulating the Wnt signaling pathway. Other

Brain, behavior, and … 2025

High Soluble Fiber Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites in Mice. Other

Gastroenterology 2024 61 次引用

Ternary inulin hydrogel with long-term intestinal retention for simultaneously reversing IBD and its fibrotic complication. Other

Nature communications 2024 60 次引用

Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity. RCT

International journal of … 2024 33 次引用

Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing … Other

Gut microbes 2024 32 次引用

Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy. Other

Nature materials 2024 28 次引用

Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism. Other

Phytomedicine : international … 2024 22 次引用

Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes. Review

Nutrients 2024 20 次引用

Dietary inulin ameliorates obesity-induced severe acute pancreatitis via gut-pancreas axis. Other

Gut microbes 2024 20 次引用

The effects of synbiotics on the liver steatosis, inflammation, and gut microbiome of metabolic dysfunction-associated liver disease patients-randomized trial. RCT

Romanian journal of … 2024 20 次引用

The Degree of Inulin Polymerization Is Important for Short-Term Amelioration of High-Fat Diet (HFD)-Induced Metabolic Dysfunction and Gut Microbiota Dysbiosis … Other

Foods (Basel, Switzerland) 2024 11 次引用

Pomegranate Juice Supplemented with Inulin Modulates Gut Microbiota and Promotes the Production of Microbiota-Associated Metabolites in Overweight/Obese Individuals: A Randomized, … RCT

Journal of agricultural … 2024 10 次引用

Colorectal cancer and microbiota: systematic review. Review

Przeglad gastroenterologiczny 2024 7 次引用

From Structure to Function: How Prebiotic Diversity Shapes Gut Integrity and Immune Balance. Review

Nutrients 2024 7 次引用

Diet composition drives tissue-specific intensity of murine enteric infections. Other

mBio 2024 5 次引用

Gut microbiome in non-alcoholic fatty liver disease. Review

Frontiers in gastroenterology … 2024 4 次引用

Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives. Review

World journal of … 2023 215 次引用

Constipation-Predominant Irritable Bowel Syndrome (IBS-C): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms. Review

Nutrients 2023 53 次引用

Effects of inulin supplementation on inflammatory biomarkers and clinical symptoms of women with obesity and depression on a calorie-restricted diet: … RCT

The British journal … 2023 22 次引用

The Effect of Prebiotic Supplements on the Gastrointestinal Microbiota and Associated Health Parameters in Pigs. Review

Animals : an … 2023 16 次引用

Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus … Other

Gut microbes 2023 15 次引用

Symbiotic Supplementation (E. faecium and Agave Inulin) Improves Spatial Memory and Increases Plasticity in the Hippocampus of Obese Rats: A … Other

Cell transplantation 2023 14 次引用

Prebiotic inulin enhances gut microbial metabolism and anti-inflammation in apolipoprotein E4 mice with sex-specific implications. Other

Scientific reports 2023 14 次引用

The Influence of Topinambur and Inulin Preventive Supplementation on Microbiota, Anxious Behavior, Cognitive Functions and Neurogenesis in Mice Exposed to … Other

Nutrients 2023 9 次引用

Components of the Fiber Diet in the Prevention and Treatment of IBD-An Update. Review

Nutrients 2022 19 次引用

Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase. Other

Journal of cellular … 2022 15 次引用

Inulin supplementation prior to mild traumatic brain injury mitigates gut dysbiosis, and brain vascular and white matter deficits in mice. Other

Frontiers in microbiomes 2022 9 次引用

Enteral feeding and the microbiome in critically ill children: a narrative review. Review

Translational pediatrics 2021 11 次引用

The effects of inulin on gut microbial composition: a systematic review of evidence from human studies. Meta-Analysis

European journal of … 2020 190 次引用

Interactions of probiotics and prebiotics with the gut microbiota. Other

Progress in molecular … 2020 58 次引用

Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice. Other

Environmental pollution (Barking, … 2020 22 次引用

Impact of Prebiotics on Enteric Diseases and Oxidative Stress. Review

Current pharmaceutical design 2020 17 次引用

Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice. Other

Endocrine journal 2019 88 次引用

The role of gut microbiota for the activity of medicinal plants traditionally used in the European Union for gastrointestinal disorders. Review

Journal of ethnopharmacology 2019 83 次引用

Effect of Low-Protein Diet and Inulin on Microbiota and Clinical Parameters in Patients with Chronic Kidney Disease. Other

Nutrients 2019 51 次引用

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. Other

Cell 2018 443 次引用

Rutin and Its Combination With Inulin Attenuate Gut Dysbiosis, the Inflammatory Status and Endoplasmic Reticulum Stress in Paneth Cells of … Other

Frontiers in microbiology 2018 73 次引用

Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases. Other

Cell host & … 2017 399 次引用

[Pathomechanism and treatment of gut microbiota dysbiosis in chronic kidney disease and interventional effects of Chinese herbal medicine]. Review

Zhongguo Zhong yao … 2017 8 次引用

Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease. Other

Digestion 2016 522 次引用

Prebiotics to fight diseases: reality or fiction? Review

Phytotherapy research : … 2013 80 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 5-10 g/day
constipationsupport:: 12 g/day for 4 weeks
prebioticmaintenance:: 5-8 g/day

上限： Well-tolerated up to 20 g/day; start low and increase gradually

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	2 weeks	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	26 weeks	Mixed	144
Inulin for 17 days during alcohol withdrawal	7 weeks	Positive	50

最佳服用时间： With meals; divide doses throughout the day to minimize gas

Safety & Side Effects

已报告的副作用

⚠ Gas and bloating (common at higher doses; start with 3-5 g/day and titrate up)
⚠ Abdominal cramping
⚠ Flatulence
⚠ Loose stools at very high doses

已知相互作用

● May enhance absorption of calcium and magnesium (beneficial interaction)
● Blood sugar-lowering medications (inulin may modestly reduce blood glucose)
● Other FODMAPs (cumulative fermentation may worsen symptoms in sensitive individuals)

可耐受最高摄入量： Well-tolerated up to 20 g/day; start low and increase gradually

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Inulin help with Gut Dysbiosis?

Based on 3 studies with 200 participants, there is preliminary evidence that needs more research that Inulin may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).

How much Inulin should I take for Gut Dysbiosis?

Studies have used various dosages. A commonly studied range is 5-10 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Inulin?

Reported side effects may include Gas and bloating (common at higher doses; start with 3-5 g/day and titrate up), Abdominal cramping, Flatulence, Loose stools at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Inulin and Gut Dysbiosis?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Gut Dysbiosis

Berberine D Medium-Chain Triglycerides (MCT Oil) D

Inulin 用于其他健康状况

Chronic Constipation B

快速结论

Increases Bifidobacterium counts (1-2 log). Whether this diversity improvement translates to clinical outcomes is unclear.

Evidence Strength30%

Low confidence

研究分析

RCT (7)Meta (1)Other (0)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Gut Dysbiosis

了解更多

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