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L-Glutamine cho Crohn's Disease

C

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

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C

Kết luận

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

Key Study Findings

Other
Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease.
Dose: None so với: None Outcome: Gut microbiota composition Hiệu quả: None None

Đối tượng nghiên cứu: Crohn's disease patients

Controlled Clinical Trial
Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study.
Dose: Washed microbiota transplantation (WMT) so với: Pre-treatment baseline Outcome: Clinical remission and multi-omics changes Hiệu quả: None None

Đối tượng nghiên cứu: Patients with Crohn's disease

Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None so với: None Outcome: Cholesterol levels Hiệu quả: None None

Đối tượng nghiên cứu: Mouse model

Observational Study n=262
Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in …
Dose: Phenylacetylglutamine (PAGln, measured) so với: Healthy controls (n=126) Outcome: PAGln association with CD and colitis Hiệu quả: None None

Đối tượng nghiên cứu: New-onset treatment-naive CD (n=136) + controls

In Vitro
Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.
Dose: Beclin1 constitutive activation (genetic) so với: Wild-type mice Outcome: Cytokine production in macrophage activation Hiệu quả: None None

Đối tượng nghiên cứu: Beclin1 variant mice + AIEC infection

Review
[Regulation of inflammatory bowel disease by amino acids].
Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: IBD patients

Key Statistics

3

Nghiên cứu

200

Người tham gia

Positive

C

Xếp hạng

Referenced Papers

Sheng wu gong … 2022 4 trích dẫn
The Cochrane database … 2018 425 trích dẫn
Gastroenterology clinics of … 2018 67 trích dẫn
Current opinion in … 2017 37 trích dẫn
The Cochrane database … 2016 37 trích dẫn
Inflammatory bowel diseases 2010 89 trích dẫn
Molecular nutrition & … 2008 26 trích dẫn
The Cochrane database … 2007 192 trích dẫn
Current opinion in … 2005 22 trích dẫn
Clinical nutrition (Edinburgh, … 2004 18 trích dẫn
Medycyna wieku rozwojowego 2004 1 trích dẫn
Alimentary pharmacology & … 2003 179 trích dẫn
Revista do Hospital … 2002 39 trích dẫn
Current opinion in … 2002 1 trích dẫn
Current opinion in … 2002
The Cochrane database … 2001 149 trích dẫn
Current opinion in … 2000 21 trích dẫn
Diseases of the … 1998 26 trích dẫn
Zeitschrift fur Gastroenterologie 1998 18 trích dẫn
Schweizerische medizinische Wochenschrift. … 1996

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:
5-15 g/day
ibsdsupport:
5 g three times daily (15 g/day total)
postexercisegut:
0.25-0.9 g/kg before intense exercise
gutbarriersupport:
0.5 g/kg/day (approximately 30-40 g/day for adults)

Giới hạn trên: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Liều lượng đã nghiên cứu

Liều lượng Thời gian Hiệu quả N
None -- Positive --
Washed microbiota transplantation (WMT) -- Positive --
None -- Positive --
Phenylacetylglutamine (PAGln, measured) -- Negative 262
Beclin1 constitutive activation (genetic) -- Positive --
None -- Mixed --
None -- Negative --
None -- Mixed --

Thời điểm dùng tốt nhất: Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

Tác dụng phụ đã được báo cáo

  • Mild gastrointestinal discomfort at high doses
  • Headache
  • Dizziness at very high doses
  • Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

Tương tác đã biết

  • Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
  • Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
  • Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

Mức hấp thụ tối đa cho phép: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does L-Glutamine help with Crohn's Disease?
Based on 3 studies with 200 participants, there is limited but promising evidence that L-Glutamine may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much L-Glutamine should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.