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Lactobacillus rhamnosus GG для Irritable Bowel Syndrome (IBS)

B

Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.

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B

Итог

Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.

Key Study Findings

Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None или: placebo Outcome: improvement in key IBS symptoms Эффект: None None

Популяция: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Randomized Controlled Trial 3 weeks Double-blind
Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review …
Dose: None или: Placebo Outcome: Pain outcomes Эффект: None None

Популяция: IBS patients

Systematic Review n=3
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic …
Dose: None или: None Outcome: Abdominal pain frequency/intensity, constipation Эффект: None None

Популяция: Children with FAPD or functional constipation

Systematic Review
Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.
Dose: various probiotic strains или: placebo Outcome: IBS symptom improvement in children Эффект: LGG showed benefit in some studies None

Популяция: Children with IBS

Review
Probiotic Bacterial and Fungal Strains: Claims with Evidence.
Dose: None или: None Outcome: None Эффект: None None

Популяция: Various populations (probiotic claims review)

Review
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Dose: None или: None Outcome: None Эффект: None None

Популяция: IBD patients

Key Statistics

8

Исследования

1200

Участники

Positive

B

Оценка

Referenced Papers

Digestive diseases (Basel, … 2016 37 цитирований
Journal of pediatric … 2016 19 цитирований
Asia Pacific journal … 2006 45 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
10-20 billion CFU/day
ibssupport:
10 billion CFU/day for 4-8 weeks
aadprevention:
10-20 billion CFU/day (start with antibiotic, continue 7 days after)

Верхний предел: Generally well-tolerated up to 40 billion CFU/day in clinical trials

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Positive --
None 3 weeks Positive --
None -- Mixed 3
various probiotic strains -- Mixed --
None -- Mixed --
None -- Mixed --
None -- Mixed --
None 26.0 weeks Mixed --

Лучшее время приёма: On an empty stomach or 30 minutes before meals for optimal survival

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
  • Rare reports of bacteremia in severely immunocompromised individuals
  • Occasional loose stools during adjustment period
  • Very rare: systemic infection in critically ill patients with central venous catheters

Известные взаимодействия

  • Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
  • Immunosuppressants (theoretical risk of infection in immunocompromised patients)
  • Antifungals (no known interaction but may affect gut flora balance)

Допустимый верхний уровень потребления: Generally well-tolerated up to 40 billion CFU/day in clinical trials

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Lactobacillus rhamnosus GG help with Irritable Bowel Syndrome (IBS)?
Based on 8 studies with 1,200 participants, there is moderate evidence from clinical studies that Lactobacillus rhamnosus GG may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Lactobacillus rhamnosus GG should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus rhamnosus GG?
Reported side effects may include Mild gas and bloating during initial use (usually resolves in 1-2 weeks), Rare reports of bacteremia in severely immunocompromised individuals, Occasional loose stools during adjustment period, Very rare: systemic infection in critically ill patients with central venous catheters. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus rhamnosus GG and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.

Related Evidence

Lactobacillus rhamnosus GG для других состояний

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.