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Inulin для Chronic Constipation

B

Meta-analysis confirms inulin (12 g/day) increases stool frequency by ~0.8 stools/week and improves stool consistency. Bifidogenic effect is well-established.

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B

Итог

Meta-analysis confirms inulin (12 g/day) increases stool frequency by ~0.8 stools/week and improves stool consistency. Bifidogenic effect is well-established.

Key Study Findings

Review
Prebiotics and Gut Health: Mechanisms, Clinical Evidence, and Future Directions.
Dose: None или: None Outcome: gut health outcomes including microbiota modulation and SCFA … Эффект: None None

Популяция: healthy individuals, children, elderly, and those with constipation, metabolic syndrome, or dysbiosis

Randomized Controlled Trial n=39 4 weeks Double-blind
Inulin-induced improvements on bowel habit and gut microbiota in adults with functional constipation: findings of …
Dose: 12 g/day chicory inulin или: Placebo (crossover design) Outcome: Stool frequency and PAC-QOL/PAC-SYM scores Эффект: None None

Популяция: Adults with functional constipation (Rome III)

Review
Dietary Fiber: A Comprehensive Review of Its Sources, Health Benefits, and Mechanisms Driving Nutraceutical Effects.
Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Controlled Clinical Trial n=20 2 weeks Open-label
Yeast mannans promote laxation and specifically modulate microbiota composition in older adults: An open-label pilot …
Dose: 15 g/day или: Baseline (pre-intervention) Outcome: GI symptoms and stool frequency Эффект: Stool freq 0.84 to 1.19/day (P=.016) P=.016

Популяция: Older adults (71.4 +/- 11.0 y)

Randomized Controlled Trial n=34 8 weeks Single-blind
A randomized trial of inulin for bowel symptoms, depression and quality of life in constipation …
Dose: 9.2 g/day total (4.6 g twice daily) или: Maltodextrin 9.2 g/day placebo Outcome: IBS-SSS score and IBS-QoL score Эффект: IBS-SSS: 267.3→195.8; IBS-QoL: 61.0→77.4 0.026 (IBS-SSS); 0.006 (QoL)

Популяция: Adults with constipation-predominant IBS

In Vitro 2 weeks
Different Efficacy of Five Soluble Dietary Fibers on Alleviating Loperamide-Induced Constipation in Mice: Influences of …
Dose: None или: Loperamide-induced constipated mice Outcome: GI transit rate, fecal moisture, gut microbiota Эффект: None p<0.05

Популяция: Loperamide-induced constipated mice (14-day study)

Key Statistics

6

Исследования

400

Участники

Positive

B

Оценка

Referenced Papers

Research in veterinary … 2024 2 цитирований
Food & function 2023 128 цитирований
Carbohydrate polymers 2022 77 цитирований
Food science & … 2022 52 цитирований
The American journal … 2021 62 цитирований
European journal of … 2020 190 цитирований
Carbohydrate polymers 2020 140 цитирований
Cellular and molecular … 2020 41 цитирований
Experimental and therapeutic … 2020 17 цитирований
Advances in food … 2019 95 цитирований
Canadian journal of … 2018 2 цитирований
Digestive diseases and … 2016 28 цитирований
Acta scientiarum polonorum. … 2014 230 цитирований
Journal of medicinal … 2011 16 цитирований
Menopause international 2009 29 цитирований
Medicinski pregled 2009 1 цитирований
Alternative medicine review … 2009
Minerva gastroenterologica e … 2006 22 цитирований
Journal of biosciences 2002 643 цитирований
The American journal … 2000 742 цитирований
Annual review of … 1998 264 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
5-10 g/day
constipationsupport:
12 g/day for 4 weeks
prebioticmaintenance:
5-8 g/day

Верхний предел: Well-tolerated up to 20 g/day; start low and increase gradually

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Positive --
12 g/day chicory inulin 4 weeks Positive 39
None -- Mixed --
15 g/day 2 weeks Positive 20
9.2 g/day total (4.6 g twice daily) 8 weeks Positive 34
None 2 weeks Positive --
None -- Positive --
Muffin with inulin, moringa, cacao -- Neutral --

Лучшее время приёма: With meals; divide doses throughout the day to minimize gas

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Gas and bloating (common at higher doses; start with 3-5 g/day and titrate up)
  • Abdominal cramping
  • Flatulence
  • Loose stools at very high doses

Известные взаимодействия

  • May enhance absorption of calcium and magnesium (beneficial interaction)
  • Blood sugar-lowering medications (inulin may modestly reduce blood glucose)
  • Other FODMAPs (cumulative fermentation may worsen symptoms in sensitive individuals)

Допустимый верхний уровень потребления: Well-tolerated up to 20 g/day; start low and increase gradually

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Inulin help with Chronic Constipation?
Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Inulin may support Chronic Constipation management. Our evidence grade is B (Good Evidence).
How much Inulin should I take for Chronic Constipation?
Studies have used various dosages. A commonly studied range is 5-10 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Inulin?
Reported side effects may include Gas and bloating (common at higher doses; start with 3-5 g/day and titrate up), Abdominal cramping, Flatulence, Loose stools at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Inulin and Chronic Constipation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Chronic Constipation

Inulin для других состояний

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.