What is the recommended dosage for Vitamin A?

General: 700-900 mcg RAE/day (RDA for adults); Gut Barrier Support: 900 mcg RAE/day from mixed sources; Deficiency Correction: 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)

What are the side effects of Vitamin A?

Potential side effects include: Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess.

What is vitamin A and how does it work for gut health?

Vitamin A is a fat-soluble vitamin essential for maintaining the integrity of mucosal surfaces throughout the body, including the intestinal lining. It supports the differentiation and function of epithelial cells that form the gut barrier, and plays a critical role in mucosal immune responses, including the production of secretory IgA. Vitamin A deficiency is associated with increased intestinal permeability and susceptibility to gastrointestinal infections.

What is the recommended dosage of vitamin A for gut health?

The recommended daily allowance is 900 mcg RAE (3,000 IU) for adult men and 700 mcg RAE (2,333 IU) for adult women. For gut health support, supplemental doses used in studies range from 5,000-10,000 IU per day. Beta-carotene (provitamin A) is a safer alternative at 15-30 mg per day, as the body converts it to vitamin A as needed, reducing toxicity risk.

Are there side effects or interactions with vitamin A?

Preformed vitamin A (retinol) can be toxic at high doses, causing nausea, headache, liver damage, and birth defects in pregnancy. The tolerable upper intake level is 3,000 mcg RAE (10,000 IU) per day for adults. Vitamin A may interact with retinoid medications (isotretinoin, tretinoin), warfarin, and hepatotoxic drugs. Pregnant women should not exceed the RDA without medical supervision.

Vitamin A
Vitamin A

vitamin

Também conhecido como: Retinol, Retinyl Palmitate, Beta-Carotene (provitamin A), Retinoic Acid

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About

Vitamin A plays a critical role in maintaining intestinal epithelial cell differentiation and turnover through retinoic acid signaling. It supports goblet cell mucus production, which forms a key component of the intestinal barrier, and is required for secretory IgA transport across mucosal surfaces. Research suggests vitamin A supplementation may help support intestinal barrier integrity and immune defense, particularly in deficient populations.

How It Works

Maintains intestinal epithelial cell differentiation and turnover via retinoic acid signaling through RAR/RXR nuclear receptors; supports goblet cell mucus production forming the protective mucus layer; required for secretory IgA transport across mucosal surfaces; modulates Th17/Treg balance in gut-associated lymphoid tissue (GALT).

Evidence For Conditions

Condição	Nota	Estudos	Participantes
Increased Intestinal Permeability (Leaky Gut)	C	3	250	Ver →
Acute Diarrhea	D	3	500	Ver →

Side Effects

Hepatotoxicity at chronic high doses of preformed vitamin A
Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
Nausea, headache, and dizziness
Bone density reduction with long-term excess

Drug & Supplement Interactions

Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
Orlistat (reduces absorption of fat-soluble vitamins)
Alcohol (increases hepatotoxicity risk of vitamin A)
Tetracycline antibiotics (increased risk of intracranial pressure)

Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.

Related Ingredients

Vitamin D

Dados Rápidos

Dosagem: General: 700-900 mcg RAE/day (RDA for adults); Gut_Barrier_Support: 900 mcg RAE/day from mixed sources; Deficiency_Correction: 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
Formas: capsule softgel liquid cod liver oil
Fontes Naturais: Liver (highest preformed source), Sweet potatoes, Carrots, Spinach, Kale, Eggs, Cod liver oil
Limite Superior: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
Melhor Horário: With meals containing fat for better absorption

Resumo das Evidências

Increased Intestinal Permeability (Leaky Gut) C

Acute Diarrhea D

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.