Vitamin D para Irritable Bowel Syndrome (IBS)
CLimited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.
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C
Conclusão
Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.
Key Study Findings
Review
Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …
Dose: None
vs: None
Outcome: IBS symptom improvement with vitamin D supplementation
Efeito: None
None
População: individuals with irritable bowel syndrome
Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None
vs: Various
Outcome: IBS symptom improvement
Efeito: Probiotics abdominal pain RR 4.04 (2.36-6.92)
None
População: Adult IBS patients
Meta-Analysis
Double-blind
The effects of vitamin D intake and status on symptom severity and quality-of-life in adults …
Dose: 3,000 IU daily to 50,000 IU bi-weekly
vs: Placebo
Outcome: IBS symptom severity and quality of life
Efeito: MD 20.33 ng/mL [12.91, 27.74] for 25(OH)D; QoL 3.1
None
População: Adults with IBS and deficient/insufficient vitamin D
Review
Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review.
Dose: None
vs: None
Outcome: Risk of developing Parkinson's disease
Efeito: None
None
População: General population (narrative review of PD risk factors)
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
vs: None
Outcome: Micronutrient deficiency management in pediatric IBD
Efeito: None
None
População: Children with inflammatory bowel disease (review)
Review
Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Dose: None
vs: None
Outcome: IBS symptom relief and pathophysiology modulation
Efeito: None
None
População: Patients with irritable bowel syndrome (review)
Key Statistics
3
Estudos
400
Participantes
↑
Positive
C
Nota
Referenced Papers
Gastroenterology nursing : …
None
4 citações
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical …
Systematic Review
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2025
10 citações
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2025
7 citações
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Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Review
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Effects of Bifidobacterium longum 35624 in Children and Adolescents with Irritable Bowel Syndrome.
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4 citações
Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and …
Systematic Review
Biological research for …
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3 citações
Irritable bowel syndrome and endometriosis: diagnosis, similarities, and nutritional management.
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2 citações
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Meta-Analysis
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Systematic Review
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2022
29 citações
The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis.
Meta-Analysis
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2022
28 citações
The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome …
Meta-Analysis
Nutrients
2022
24 citações
PloS one
2022
10 citações
Nutricion hospitalaria
2022
9 citações
Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults.
Other
Nutrients
2022
7 citações
Journal of gastroenterology …
2022
4 citações
Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review.
Systematic Review
Nutrients
2021
16 citações
Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome.
Other
Journal of gastroenterology …
2021
10 citações
Zhongguo dang dai …
2021
The journal of …
2020
294 citações
The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis.
Meta-Analysis
Osteoporosis international : …
2020
14 citações
Cureus
2020
10 citações
Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D.
Review
Expert review of …
2019
33 citações
Medicine
2019
4 citações
Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what …
Systematic Review
European journal of …
2018
39 citações
Saudi journal of …
2018
38 citações
The Australian and …
2017
280 citações
Current gastroenterology reports
2017
157 citações
PloS one
2017
38 citações
PloS one
2017
5 citações
World journal of …
2016
238 citações
Nutrients
2016
55 citações
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
Review
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2016
41 citações
Clinics in dermatology
2016
19 citações
World journal of …
2015
62 citações
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2015
56 citações
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Other
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2014
38 citações
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2012
225 citações
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2012
224 citações
Dietary supplements for established atopic eczema.
Meta-Analysis
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130 citações
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2011
23 citações
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 600-800 IU/day (RDA)
- ibdsupport:
- 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
- deficiencycorrection:
- 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance
Limite superior: 4,000 IU/day (100 mcg); higher doses under medical supervision only
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 3,000 IU daily to 50,000 IU bi-weekly | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 240 |
Melhor horário: With a meal containing fat for better absorption
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
- ⚠ Kidney stones with excessive long-term supplementation
- ⚠ Constipation
- ⚠ Metallic taste
Interações Conhecidas
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Ingestão máxima tolerável: 4,000 IU/day (100 mcg); higher doses under medical supervision only
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Vitamin D help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 400 participants, there is limited but promising evidence that Vitamin D may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Vitamin D should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Irritable Bowel Syndrome (IBS)
Vitamin D para outras condições
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.