Zinc ： Acute Diarrhea

WHO/UNICEF recommend zinc (20 mg/day for 10-14 days) for all children with acute diarrhea. Reduces duration by ~25% and decreases subsequent diarrhea episodes for 2-3 months.

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結論

WHO/UNICEF recommend zinc (20 mg/day for 10-14 days) for all children with acute diarrhea. Reduces duration by ~25% and decreases subsequent diarrhea episodes for 2-3 months.

Key Study Findings

Review

The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; …

Dose: None vs: None Outcome: None 効果: None None

対象集団: children with persistent diarrhea, lactose intolerance, and gut dysbiosis in low/middle-income countries

Other

Clinical practice guidelines for acute infectious diarrhea in children in China (2024).

Dose: None vs: None Outcome: None 効果: None None

対象集団: Clinical practice guidelines for pediatric acute diarrhea

Randomized Controlled Trial Open-label

Mobile phone call reminders to improve oral rehydration salt and zinc adherence for acute diarrhea …

Dose: ORS and zinc tablets vs: Standard care (no reminders) Outcome: ORS and zinc adherence rates 効果: None None

対象集団: Children <5 with acute diarrhea

Other

Has Zinc Lost Its Shine?

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Review

Lactose intolerance: myths and facts. An update.

Dose: None vs: None Outcome: Lactose digestion and tolerance management 効果: None None

対象集団: Lactose intolerant individuals

Randomized Controlled Trial n=454 1 weeks Double-blind

Efficacy and safety of Bacillus clausii (O/C, N/R, SIN, T) probiotic combined with oral rehydration …

Dose: 2 billion spores/5mL BID x 5 days vs: Placebo + ORT + zinc Outcome: Duration of acute diarrhea 効果: Median 42.83h vs 42.13h (HR 0.93, 95%CI 0.77-1.13) p=0.70

対象集団: Children 6mo-5y with acute moderate diarrhea in India

Key Statistics

研究数

10000

参加者数

↑

Positive

グレード

Referenced Papers

The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; a comprehensive review. Other

BMC pediatrics 2026

Clinical practice guidelines for acute infectious diarrhea in children in China (2024). Other

World journal of … 2025 2 件の引用

Mobile phone call reminders to improve oral rehydration salt and zinc adherence for acute diarrhea in children: a single-center, randomized … RCT

BMC health services … 2024 1 件の引用

Lactose intolerance: myths and facts. An update. Review

Archivos argentinos de … 2022 42 件の引用

Efficacy and safety of Bacillus clausii (O/C, N/R, SIN, T) probiotic combined with oral rehydration therapy (ORT) and zinc in … Other

Tropical diseases, travel … 2022 17 件の引用

Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues for a personalized dosage regimen. Other

Nutrition reviews 2022 3 件の引用

Has Zinc Lost Its Shine? Other

The Journal of … 2022

Modeling Enteropathy or Diarrhea with the Top Bacterial and Protozoal Pathogens: Differential Determinants of Outcomes. Review

ACS infectious diseases 2021 26 件の引用

Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … RCT

Journal of dairy … 2020 58 件の引用

Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. RCT

The New England … 2020 50 件の引用

Treating Viral Diarrhea in Children by Probiotic and Zinc Supplements. Other

Pediatric gastroenterology, hepatology … 2019 17 件の引用

Effect of Zinc Supplementation on the Frequency and Consistency of Stool in Children with Acute Diarrhea. Other

Cureus 2019 11 件の引用

[Skin Manifestations of Pellagra]. Other

Brain and nerve … 2019 1 件の引用

Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. Meta-Analysis

PloS one 2018 76 件の引用

Chinese clinical practice guidelines for acute infectious diarrhea in children. Review

World journal of … 2018 52 件の引用

Management of minor ailments in a community pharmacy setting: Findings from simulated visits and qualitative study in Gondar town, Ethiopia. Other

PloS one 2018 48 件の引用

Non-prescribed sale of antibiotics for acute childhood diarrhea and upper respiratory tract infection in community pharmacies: a 2 phase mixed-methods … Other

Antimicrobial resistance and … 2018 46 件の引用

Interventions to reduce post-acute consequences of diarrheal disease in children: a systematic review. Systematic Review

BMC public health 2018 23 件の引用

Approach to "Upset Stomach". Review

Indian journal of … 2017 1 件の引用

Effects of zinc or synbiotic on the duration of diarrhea in children with acute infectious diarrhea. RCT

The Turkish journal … 2016 36 件の引用

Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: A 12-month randomised … RCT

Allergologia et immunopathologia 2016 31 件の引用

Oral zinc provision in acute diarrhea. Review

Current opinion in … 2016 13 件の引用

[Therapeutic effects of zinc supplement as adjunctive therapy in infants and young children with rotavirus enteritis]. RCT

Zhongguo dang dai … 2016 9 件の引用

The effectiveness and safety of treatments used for acute diarrhea and acute gastroenteritis in children: protocol for a systematic review … Other

Systematic reviews 2016

Pharmacy-based dispensing of antimicrobial agents without prescription in India: appropriateness and cost burden in the private sector. Other

Antimicrobial resistance and … 2015 113 件の引用

Oral zinc and common childhood infections--An update. Review

Journal of trace … 2015 33 件の引用

Serum levels of vitamins A and D, and zinc in children with acute diarrhea: A cross-sectional study. Other

Medical journal of … 2015 15 件の引用

Zinc supplementation in acute diarrhea. Meta-Analysis

Indian journal of … 2015 13 件の引用

Zinc for Acute Diarrhea and Amoxicillin for Pneumonia, Do They Work? : Delivered at the AIIMS, IJP Excellence Award for … Other

Indian journal of … 2015 4 件の引用

Infectious diarrhea: an overview. Review

Current gastroenterology reports 2014 40 件の引用

Management of acute infectious diarrhea for children living in resource-limited settings. Review

Expert review of … 2014 37 件の引用

Discovery of human zinc deficiency: its impact on human health and disease. Review

Advances in nutrition … 2013 807 件の引用

Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis. Meta-Analysis

Nutrients 2013 89 件の引用

Zinc supplementation in public health. Review

Annals of nutrition … 2013 82 件の引用

Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis. Meta-Analysis

Revista panamericana de … 2013 38 件の引用

Management of acute diarrhea in emergency room. Review

Indian journal of … 2013 26 件の引用

Zinc and copper supplementation are not cost-effective interventions in the treatment of acute diarrhea. RCT

Journal of clinical … 2013 15 件の引用

The management of acute diarrhea in children in developed and developing areas: from evidence base to clinical practice. Review

Expert opinion on … 2012 73 件の引用

New actions for old nutrients. Review

Acta scientiarum polonorum. … 2012 11 件の引用

Roles of zinc in the pathophysiology of acute diarrhea. Other

Current infectious disease … 2012

Mechanisms of action of zinc in acute diarrhea. Review

Current opinion in … 2011 59 件の引用

Update on prolonged and persistent diarrhea in children. Review

Current opinion in … 2011 31 件の引用

Zinc, vitamin A, and micronutrient supplementation in children with diarrhea: a randomized controlled clinical trial of combination therapy versus monotherapy. RCT

The Journal of … 2011 30 件の引用

Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review. Meta-Analysis

PloS one 2010 114 件の引用

Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery. RCT

European journal of … 2010 51 件の引用

Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Review

Food and nutrition … 2009 313 件の引用

Zinc deficiency. Review

Current opinion in … 2009 72 件の引用

Zinc and copper supplementation in acute diarrhea in children: a double-blind randomized controlled trial. RCT

BMC medicine 2009 45 件の引用

A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Meta-Analysis

Pediatrics 2008 180 件の引用

Zinc and diarrheal disease: current status and future perspectives. Review

Current opinion in … 2008 55 件の引用

Comparison of the effects of zinc delivered in a fortified food or a liquid supplement on the growth, morbidity, and … RCT

The American journal … 2007 106 件の引用

Zinc supplementation reduced cost and duration of acute diarrhea in children. RCT

Journal of clinical … 2007 48 件の引用

Probiotics and zinc in acute infectious gastroenteritis in children: are they effective? Review

Nutrition (Burbank, Los … 2007 39 件の引用

[Feeding infants and young children with acute diarrhea]. Review

Archives de pediatrie … 2007 13 件の引用

Zinc in the treatment of acute diarrhea: current status and assessment. Review

Gastroenterology 2006 93 件の引用

Zinc supplementation in acute diarrhea is acceptable, does not interfere with oral rehydration, and reduces the use of other medications: … RCT

Journal of pediatric … 2006 55 件の引用

Effect of infections and environmental factors on growth and nutritional status in developing countries. Other

Journal of pediatric … 2006 54 件の引用

Estimation of serum zinc and copper in children with acute diarrhea. Other

Biological trace element … 2006 27 件の引用

Zinc supplementation and serum zinc during diarrhea. Other

Indian journal of … 2006 25 件の引用

Zinc and pneumonia. Other

The American journal … 2006 23 件の引用

Zinc and infection: a review. Review

Annals of tropical … 2005 92 件の引用

Therapeutic evaluation of zinc and copper supplementation in acute diarrhea in children: double blind randomized trial. RCT

Indian pediatrics 2005

Zinc deficiency, infectious disease and mortality in the developing world. Review

The Journal of … 2003 359 件の引用

Treatment of infectious diarrhea in children. Review

Paediatric drugs 2003 125 件の引用

Economic evaluation of zinc and copper use in treating acute diarrhea in children: A randomized controlled trial. Other

Cost effectiveness and … 2003 32 件の引用

Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil. Other

Journal of health, … 2003

Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. Other

MMWR. Recommendations and … 2003

Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. RCT

Pediatrics 2002 154 件の引用

Micronutrient deficiency in children. Other

The British journal … 2001 74 件の引用

Micronutrients as adjunct therapy of acute illness in children: impact on the episode outcome and policy implications of current findings. Other

The British journal … 2001 30 件の引用

Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled … Other

The American journal … 2000 556 件の引用

Zinc, diarrhea, and pneumonia. Other

The Journal of … 1999 37 件の引用

Management of acute diarrhea in infants. Review

JPEN. Journal of … 1999 26 件の引用

Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. Review

The American journal … 1998 252 件の引用

Zinc and micronutrient supplements for children. Review

The American journal … 1998 121 件の引用

Possibilities for zinc in the treatment of acute diarrhea. Review

The American journal … 1998 28 件の引用

Chronic diarrhea in infancy and childhood. Review

The Journal of … 1998 3 件の引用

[Acrodermatitis enteropathica; a literature review]. Review

Nederlands tijdschrift voor … 1991

Serum and rectal mucosal zinc levels in acute and chronic diarrhea. Other

Indian pediatrics 1990 8 件の引用

Zinc in hair and urine of paediatric patients. Other

Clinica chimica acta; … 1986 15 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 8-11 mg/day (RDA for adults)
infantdiarrhea:: 10 mg/day for 10-14 days (WHO recommendation for infants <6 months)
pediatricdiarrhea:: 20 mg/day for 10-14 days (WHO recommendation for children >6 months)
gutbarriersupport:: 15-30 mg/day elemental zinc

上限量： 40 mg/day elemental zinc for adults (risk of copper depletion above this level)

研究で検討された用量

用量	期間	効果	N
None	--	Neutral	--
None	--	Mixed	--
ORS and zinc tablets	--	Positive	--
None	--	Mixed	--
None	--	Neutral	--
2 billion spores/5mL BID x 5 days	1 weeks	Neutral	454
None	--	Positive	--
None	--	Positive	--

推奨摂取タイミング： With food to reduce nausea; space from antibiotics and iron by 2 hours

Safety & Side Effects

報告されている副作用

⚠ Nausea and vomiting (most common, especially on empty stomach)
⚠ Metallic taste
⚠ Copper depletion with long-term supplementation above 40 mg/day
⚠ Diarrhea (paradoxically, at high doses)

既知の相互作用

● Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
● Penicillamine (zinc reduces absorption; space 2 hours)
● Iron supplements (mutual inhibition of absorption; take at different times)
● Copper supplements (zinc competes with copper for absorption)

耐容上限摂取量： 40 mg/day elemental zinc for adults (risk of copper depletion above this level)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Zinc help with Acute Diarrhea?

Based on 33 studies with 10,000 participants, there is strong evidence from multiple clinical trials that Zinc may support Acute Diarrhea management. Our evidence grade is A (Strong Evidence).

How much Zinc should I take for Acute Diarrhea?

Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Zinc?

Reported side effects may include Nausea and vomiting (most common, especially on empty stomach), Metallic taste, Copper depletion with long-term supplementation above 40 mg/day, Diarrhea (paradoxically, at high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Zinc and Acute Diarrhea?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 33 peer-reviewed studies with 10,000 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Acute Diarrhea

Berberine C Vitamin A D Bovine Colostrum D

総合評価

WHO/UNICEF recommend zinc (20 mg/day for 10-14 days) for all children with acute diarrhea. Reduces duration by ~25% and decreases subsequent diarrhea episodes for 2-3 months.

Evidence Strength92%

High confidence

研究の内訳

RCT (15)Meta (6)Other (12)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Acute Diarrhea

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