Fructooligosaccharides (FOS) ： Chronic Constipation
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Some studies show increased stool frequency. Bifidogenic effect well-established but clinical laxation effect more modest than inulin.
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C
結論
Some studies show increased stool frequency. Bifidogenic effect well-established but clinical laxation effect more modest than inulin.
Key Study Findings
Review
Prebiotics and Gut Health: Mechanisms, Clinical Evidence, and Future Directions.
Dose: None
vs: None
Outcome: gut health outcomes including microbiota modulation and SCFA …
効果: None
None
対象集団: healthy individuals, children, elderly, and those with constipation, metabolic syndrome, or dysbiosis
Randomized Controlled Trial
n=67
4 weeks
Double-blind
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …
Dose: None
vs: Placebo
Outcome: Weekly spontaneous bowel movements
効果: 4.94 vs 3.00 (P<0.001)
P<0.001
対象集団: Older adults >=60 with functional constipation (Rome IV)
Other
Maternal or post-weaning dietary fructo-oligosaccharide supplementation reduces stillbirth rate of sows and diarrhea of weaned …
Dose: 2 g
vs: None
Outcome: Constipation symptoms
効果: None
P < 0.05
対象集団: Constipation patients
Randomized Controlled Trial
Double-blind
Xylo-oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium.
Dose: 6 g
vs: Placebo
Outcome: Constipation symptoms
効果: None
None
対象集団: Constipation patients
Systematic Review
Fructooligosaccharides for Relieving Functional Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Dose: None
vs: None
Outcome: Constipation symptoms
効果: OR: 10.36
p < 0.00001
対象集団: Constipation patients
Randomized Controlled Trial
Double-blind
Advice to People with Parkinson's in My Clinic: Probiotics and Prebiotics.
Dose: None
vs: Placebo
Outcome: Constipation symptoms
効果: None
None
対象集団: Constipation patients
Key Statistics
4
研究数
350
参加者数
↑
Positive
C
グレード
Referenced Papers
Nutrients
2026
1 件の引用
The journal of …
2025
Xylo-oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium.
Other
Food science & …
2024
17 件の引用
Foods (Basel, Switzerland)
2024
8 件の引用
Journal of Parkinson's …
2024
4 件の引用
Animal nutrition (Zhongguo …
2024
4 件の引用
Carbohydrate polymers
2022
77 件の引用
Frontiers in nutrition
2022
22 件の引用
Nutrients
2019
35 件の引用
Nutrients
2018
30 件の引用
Journal of the …
2017
447 件の引用
Neurogastroenterology and motility
2017
131 件の引用
Nutrients
2017
28 件の引用
Clinical nutrition (Edinburgh, …
2017
20 件の引用
Peritoneal dialysis international …
2016
38 件の引用
World journal of …
2014
16 件の引用
Clinical nutrition (Edinburgh, …
2013
Nutrition (Burbank, Los …
2011
65 件の引用
Journal of medicinal …
2011
24 件の引用
Journal of physiology …
2009
312 件の引用
Journal of the …
2007
84 件の引用
BioFactors (Oxford, England)
2004
48 件の引用
The British journal …
2003
97 件の引用
Journal of renal …
1998
71 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 2-10 g/day
- prebioticeffect:
- 5-8 g/day for bifidogenic effect
- constipationsupport:
- 5-10 g/day
上限量： Well-tolerated up to 20 g/day; start low to avoid excess gas
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | 4 weeks | Positive | 67 |
| 2 g | -- | Neutral | -- |
| 6 g | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals; divide doses throughout the day
Safety & Side Effects
報告されている副作用
- ⚠ Gas, bloating, and flatulence (dose-dependent; more common above 10 g/day)
- ⚠ Abdominal cramping at higher doses
- ⚠ May worsen IBS symptoms in FODMAP-sensitive individuals
- ⚠ Loose stools at excessive doses
既知の相互作用
- ● Other FODMAPs (cumulative fermentation effect in sensitive individuals)
- ● Blood sugar-lowering medications (FOS may modestly affect glycemic response)
- ● Calcium supplements (FOS may enhance calcium absorption)
耐容上限摂取量： Well-tolerated up to 20 g/day; start low to avoid excess gas
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Fructooligosaccharides (FOS) help with Chronic Constipation?
Based on 4 studies with 350 participants, there is limited but promising evidence that Fructooligosaccharides (FOS) may support Chronic Constipation management. Our evidence grade is C (Some Evidence).
How much Fructooligosaccharides (FOS) should I take for Chronic Constipation?
Studies have used various dosages. A commonly studied range is 2-10 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Fructooligosaccharides (FOS)?
Reported side effects may include Gas, bloating, and flatulence (dose-dependent; more common above 10 g/day), Abdominal cramping at higher doses, May worsen IBS symptoms in FODMAP-sensitive individuals, Loose stools at excessive doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Fructooligosaccharides (FOS) and Chronic Constipation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Chronic Constipation
Fructooligosaccharides (FOS) 他の症状・状態について
References
- [1] Cinara Regina A V Monteiro et al.. Nutrients. 2026. Prebiotics and Gut Health: Mechanisms, Clinical Evidence, and Future Directions. doi:10.3390/nu18030372 PubMed
- [2] Meina Li et al.. J Nutr Health Aging. 2025. Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, … doi:10.1016/j.jnha.2025.100598 PubMed
- [3] Wanya Yi et al.. Food Sci Nutr. 2024. Xylo-oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium. doi:10.1002/fsn3.3827 PubMed
- [4] Hongmin Zhen et al.. Foods. 2024. Fructooligosaccharides for Relieving Functional Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. doi:10.3390/foods13243993 PubMed
- [5] Jia Wei Hor et al.. J Parkinsons Dis. 2024. Advice to People with Parkinson's in My Clinic: Probiotics and Prebiotics. doi:10.3233/JPD-240172 PubMed
- [6] Kaidi Ma et al.. Anim Nutr. 2024. Maternal or post-weaning dietary fructo-oligosaccharide supplementation reduces stillbirth rate of sows and diarrhea of weaned piglets. doi:10.1016/j.aninu.2024.04.002 PubMed
- [7] Ashinshana U Illippangama et al.. Carbohydr Polym. 2022. Inulin as a functional ingredient and their applications in meat products. doi:10.1016/j.carbpol.2021.118706 PubMed
- [8] Qi Zhang et al.. Front Nutr. 2022. In vitro Study of Bifidobacterium lactis BL-99 With Fructooligosaccharide Synbiotics Effected on the Intestinal Microbiota. doi:10.3389/fnut.2022.890316 PubMed
- [9] Jan de Vries et al.. Nutrients. 2019. Effects of β-Fructans Fiber on Bowel Function: A Systematic Review and Meta-Analysis. doi:10.3390/nu11010091 PubMed
- [10] Daniela da Silva Souza et al.. Nutrients. 2018. Randomized, Double-Blind, Placebo-Controlled Parallel Clinical Trial Assessing the Effect of Fructooligosaccharides in Infants with Constipation. doi:10.3390/nu10111602 PubMed
- [11] Johnson W McRorie et al.. J Acad Nutr Diet. 2017. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring Misconceptions about Insoluble and … doi:10.1016/j.jand.2016.09.021 PubMed
- [12] F Azpiroz et al.. Neurogastroenterol Motil. 2017. Effects of scFOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double … doi:10.1111/nmo.12911 PubMed
- [13] Shinji Jinno et al.. Nutrients. 2017. Maternal Prebiotic Ingestion Increased the Number of Fecal Bifidobacteria in Pregnant Women but Not in Their Neonates Aged One Month. doi:10.3390/nu9030196 PubMed
- [14] Annelisa Silva E Alves de Carvalho Santos et al.. Clin Nutr. 2017. Effectiveness of nutritional treatment and synbiotic use on gastrointestinal symptoms reduction in HIV-infected patients: Randomized clinical trial. doi:10.1016/j.clnu.2016.06.005 PubMed
- [15] Kulwara Meksawan et al.. Perit Dial Int. 2016. Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients. doi:10.3747/pdi.2014.00015 PubMed
- [16] Petra A M J Scholtens et al.. World J Gastroenterol. 2014. Stool characteristics of infants receiving short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides: a review. doi:10.3748/wjg.v20.i37.13446 PubMed
- [17] Dan L Waitzberg et al.. Clin Nutr. 2013. Effect of synbiotic in constipated adult women - a randomized, double-blind, placebo-controlled study of clinical response. doi:10.1016/j.clnu.2012.08.010 PubMed
- [18] Chi-Hua Yen et al.. Nutrition. 2011. Beneficial effects of fructo-oligosaccharides supplementation on fecal bifidobacteria and index of peroxidation status in constipated nursing-home residents--a placebo-controlled, diet-controlled trial. doi:10.1016/j.nut.2010.02.009 PubMed
- [19] Esther Nova et al.. J Med Food. 2011. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. doi:10.1089/jmf.2008.0328 PubMed
- [20] M Sabater-Molina et al.. J Physiol Biochem. 2009. Dietary fructooligosaccharides and potential benefits on health. doi:10.1007/BF03180584 PubMed
- [21] Syed H Tariq. J Am Med Dir Assoc. 2007. Constipation in long-term care. doi:10.1016/j.jamda.2007.02.009 PubMed
- [22] Takahisa Tokunaga. Biofactors. 2004. Novel physiological function of fructooligosaccharides. doi:10.1002/biof.552210117 PubMed
- [23] Nancy Moore et al.. Br J Nutr. 2003. Effects of fructo-oligosaccharide-supplemented infant cereal: a double-blind, randomized trial. doi:10.1079/bjn2003950 PubMed
- [24] D B Cockram et al.. J Ren Nutr. 1998. Safety and tolerance of medical nutritional products as sole sources of nutrition in people on hemodialysis. doi:10.1016/s1051-2276(98)90034-6 PubMed
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