What is the recommended dosage for Lactobacillus casei?

General: 1-10 billion CFU/day; Aad Prevention: 6.5 billion CFU/day (Shirota strain); Immune Support: 10 billion CFU/day

What are the side effects of Lactobacillus casei?

Potential side effects include: Mild gas and bloating during initial use, Occasional loose stools, Rare dairy-related reactions in lactose-sensitive individuals, Very rare: bacteremia in immunocompromised individuals.

What is Lactobacillus casei and how does it work for gut health?

Lactobacillus casei is a probiotic bacterium commonly found in fermented foods and the human digestive tract. It produces lactic acid, helps regulate the gut microbial balance, and may enhance mucosal immune responses. The strain L. casei Shirota, used in Yakult, is one of the most extensively studied probiotics for digestive health worldwide.

What is the recommended dosage of Lactobacillus casei?

Studies with L. casei have used dosages from 1 billion to 40 billion CFU per day. The strain L. casei Shirota is typically consumed at about 6.5 billion CFU per serving (one bottle of Yakult). For supplement forms, 5-10 billion CFU daily is a commonly studied dosage with demonstrated effects on digestive symptoms.

Are there side effects or interactions with Lactobacillus casei?

L. casei has a strong safety record supported by decades of commercial use in probiotic beverages and supplements. Side effects are rare and typically limited to mild gas or bloating. As with other Lactobacillus species, it should be taken at least 2 hours apart from antibiotics, and immunocompromised individuals should seek medical advice before use.

Lactobacillus casei

probiotic_strain

Also known as: L. casei, Lacticaseibacillus casei, Shirota, DN-114 001, Yakult

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About

Lactobacillus casei is a widely consumed probiotic species found in fermented dairy products. It supports immune function by enhancing phagocytic activity of macrophages and may help modulate the Th1/Th2 immune balance. Research suggests the Shirota strain (found in Yakult) may help support digestive comfort and antibiotic-associated digestive resilience.

How It Works

Enhances phagocytic activity of macrophages and modulates Th1/Th2 immune balance; produces organic acids (lactic, acetic) inhibiting enteric pathogens; supports colonization resistance against pathogenic bacteria; stimulates secretory IgA production at mucosal surfaces.

Evidence For Conditions

Condition	Grade	Studies	Participants
Antibiotic-Associated Diarrhea (AAD)	C	3	500	View →

Side Effects

Mild gas and bloating during initial use
Occasional loose stools
Rare dairy-related reactions in lactose-sensitive individuals
Very rare: bacteremia in immunocompromised individuals

Drug & Supplement Interactions

Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
Immunosuppressants (theoretical risk in immunocompromised patients)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Bacillus coagulans Bifidobacterium bifidum Bifidobacterium breve Bifidobacterium lactis Bifidobacterium longum

Quick Facts

Dosage: General: 1-10 billion CFU/day; Aad_Prevention: 6.5 billion CFU/day (Shirota strain); Immune_Support: 10 billion CFU/day
Forms: capsule fermented milk drink powder tablet
Natural Sources: Yakult (fermented milk drink), Cheese (naturally occurring in aging), Fermented dairy products, Pickled vegetables
Upper Limit: Well-tolerated up to 20 billion CFU/day in clinical trials
Best Time: With or without food; consistent daily timing recommended

Evidence Summary

Antibiotic-Associated Diarrhea (AAD) C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.