Saccharomyces boulardii untuk Traveler's Diarrhea
BRCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.
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B
Kesimpulan
RCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.
Key Study Findings
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: placebo
Outcome: improvement in key IBS symptoms
Efek: None
None
Populasi: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Randomized Controlled Trial
n=47
8 weeks
Double-blind
Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and …
Dose: None
vs: Placebo (Group I) and partial formulation (Group II)
Outcome: IBS quality of life (QoL questionnaire)
Efek: Dysphoria: median diff -5 (Group III) vs -1 (contr
0.0021 (dysphoria Group III)
Populasi: Patients with IBS
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
vs: None
Outcome: Clinical guideline recommendations for pediatric GI
Efek: None
None
Populasi: Pediatric patients with GI disorders
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
vs: None
Outcome: Probiotic prescribing habits of Italian PCPs
Efek: L. rhamnosus GG used by 91.8%
None
Populasi: Italian primary care pediatricians
Other
n=70
16 weeks
Open-label
Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study.
Dose: None
vs: None (single-arm study)
Outcome: Constipation scoring system change
Efek: -5.3 (95% CI -5.9/-4.7)
0.001
Populasi: Peritoneal dialysis patients with chronic constipation
Review
An update on probiotics in paediatrics.
Dose: None
vs: None
Outcome: GI disorder outcomes in paediatrics
Efek: None
None
Populasi: Paediatric patients with GI disorders
Key Statistics
4
Studi
3200
Peserta
↑
Positive
B
Peringkat
Referenced Papers
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Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children.
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5 sitasi
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1 sitasi
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23 sitasi
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2021
35 sitasi
Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections.
Review
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2019
92 sitasi
Probiotics and antimicrobial …
2019
43 sitasi
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2019
25 sitasi
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17 sitasi
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450 sitasi
Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.
Systematic Review
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2018
132 sitasi
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2015
5 sitasi
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14 sitasi
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2014
3 sitasi
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2014
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2013
263 sitasi
The American journal …
2012
104 sitasi
Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use.
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2012
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2012
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265 sitasi
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918 sitasi
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Meta-Analysis
CMAJ : Canadian …
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197 sitasi
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 sitasi
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2006
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2001
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181 sitasi
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 250-500 mg/day (equivalent to 5-10 billion CFU)
- aadprevention:
- 500 mg/day (start with antibiotic, continue 7 days after)
- cdiffprevention:
- 500 mg twice daily as adjunct to standard therapy
- travelersdiarrhea:
- 250-500 mg/day starting 5 days before travel
Batas atas: Well-tolerated up to 1,000 mg/day in clinical trials
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | 8 weeks | Positive | 47 |
| None | -- | Positive | -- |
| None | -- | Mixed | 279 |
| None | 16 weeks | Positive | 70 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
Waktu terbaik diminum: Can be taken with or without food; space 2 hours from antifungals
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Mild gas and bloating
- ⚠ Rare: fungemia in critically ill patients with central venous catheters
- ⚠ Thirst (yeast may increase water requirements)
- ⚠ Very rare: potential environmental contamination risk in ICU settings
Interaksi yang Diketahui
- ● Antifungal medications (may kill S. boulardii, reducing effectiveness)
- ● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
- ● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)
Asupan atas yang dapat ditoleransi: Well-tolerated up to 1,000 mg/day in clinical trials
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Saccharomyces boulardii help with Traveler's Diarrhea?
Based on 4 studies with 3,200 participants, there is moderate evidence from clinical studies that Saccharomyces boulardii may support Traveler's Diarrhea management. Our evidence grade is B (Good Evidence).
How much Saccharomyces boulardii should I take for Traveler's Diarrhea?
Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saccharomyces boulardii?
Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saccharomyces boulardii and Traveler's Diarrhea?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 3,200 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Traveler's Diarrhea
Saccharomyces boulardii untuk kondisi lain
Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.