Lactobacillus rhamnosus GG para Antibiotic-Associated Diarrhea (AAD)
A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.Meta-analyses demonstrate LGG reduces AAD incidence by 42-49%. Most effective when started within 48 hours of antibiotic initiation and continued 7 days after completion.
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A
Conclusión
Meta-analyses demonstrate LGG reduces AAD incidence by 42-49%. Most effective when started within 48 hours of antibiotic initiation and continued 7 days after completion.
Key Study Findings
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
vs: None
Outcome: Probiotic prescribing habits of Italian PCPs
Efecto: L. rhamnosus GG used by 91.8%
None
Población: Italian primary care pediatricians
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
vs: None
Outcome: Clinical guideline recommendations for pediatric GI
Efecto: None
None
Población: Pediatric patients with GI disorders
Controlled Clinical Trial
n=24
2 weeks
Protective Effect of Probiotics on Cardiac Damage in Experimental Sepsis Model Induced by Lipopolysaccharide in …
Dose: 10^9 CFU/day for 14 days
vs: LPS-only group (no probiotics)
Outcome: Cardiac damage markers (CK-MB, cTn-I, cytokines)
Efecto: None
p<0.05 to <0.001
Población: Male Wistar albino rats with LPS-induced sepsis
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Pediatric population
Randomized Controlled Trial
Double-blind
A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea …
Dose: Probiotics (multi-strain)
vs: Placebo
Outcome: Antibiotic-associated diarrhea incidence
Efecto: None
None
Población: Adult patients receiving antibiotics
Review
Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review.
Dose: S. boulardii CNCM I-745
vs: Placebo or standard care
Outcome: AAD prevention and pediatric gastroenteritis
Efecto: None
None
Población: AAD and gastroenteritis patients (review)
Key Statistics
20
Estudios
4000
Participantes
↑
Positive
A
Calificación
Referenced Papers
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 citas
Medicina (Kaunas, Lithuania)
2025
1 citas
Antibiotics (Basel, Switzerland)
2025
Boletin medico del …
2025
Cureus
2024
1 citas
Cureus
2023
19 citas
Archivos argentinos de …
2022
23 citas
Canadian journal of …
2022
6 citas
International journal of …
2020
32 citas
Pediatric gastroenterology, hepatology …
2020
20 citas
Pharmacological research
2018
132 citas
A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands.
Meta-Analysis
BMC gastroenterology
2018
80 citas
United European gastroenterology …
2018
66 citas
Probiotics and antimicrobial …
2018
26 citas
World journal of …
2017
68 citas
Journal of pediatric …
2016
233 citas
Digestive diseases (Basel, …
2016
37 citas
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 citas
Journal of clinical …
2015
35 citas
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 citas
Nutricion hospitalaria
2015
5 citas
Medycyna wieku rozwojowego
2012
1 citas
Current opinion in …
2009
82 citas
Advances in biochemical …
2008
535 citas
The Journal of …
2007
265 citas
The American journal …
2006
918 citas
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 citas
Inflammation
2002
37 citas
The American journal …
2001
648 citas
Inflammation
2001
101 citas
The Journal of …
1999
559 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 10-20 billion CFU/day
- ibssupport:
- 10 billion CFU/day for 4-8 weeks
- aadprevention:
- 10-20 billion CFU/day (start with antibiotic, continue 7 days after)
Límite superior: Generally well-tolerated up to 40 billion CFU/day in clinical trials
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Mixed | 279 |
| None | -- | Positive | -- |
| 10^9 CFU/day for 14 days | 2 weeks | Positive | 24 |
| None | -- | Mixed | -- |
| Probiotics (multi-strain) | -- | Positive | -- |
| S. boulardii CNCM I-745 | -- | Positive | -- |
| None | -- | Positive | -- |
| Twice daily | -- | Neutral | 2650 |
Mejor momento para tomar: On an empty stomach or 30 minutes before meals for optimal survival
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
- ⚠ Rare reports of bacteremia in severely immunocompromised individuals
- ⚠ Occasional loose stools during adjustment period
- ⚠ Very rare: systemic infection in critically ill patients with central venous catheters
Interacciones conocidas
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk of infection in immunocompromised patients)
- ● Antifungals (no known interaction but may affect gut flora balance)
Ingesta máxima tolerable: Generally well-tolerated up to 40 billion CFU/day in clinical trials
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Lactobacillus rhamnosus GG help with Antibiotic-Associated Diarrhea (AAD)?
Based on 20 studies with 4,000 participants, there is strong evidence from multiple clinical trials that Lactobacillus rhamnosus GG may support Antibiotic-Associated Diarrhea (AAD) management. Our evidence grade is A (Strong Evidence).
How much Lactobacillus rhamnosus GG should I take for Antibiotic-Associated Diarrhea (AAD)?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus rhamnosus GG?
Reported side effects may include Mild gas and bloating during initial use (usually resolves in 1-2 weeks), Rare reports of bacteremia in severely immunocompromised individuals, Occasional loose stools during adjustment period, Very rare: systemic infection in critically ill patients with central venous catheters. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus rhamnosus GG and Antibiotic-Associated Diarrhea (AAD)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 20 peer-reviewed studies with 4,000 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Antibiotic-Associated Diarrhea (AAD)
Lactobacillus rhamnosus GG para otras condiciones
References
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Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.