Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection.

Atsushi Ushiyama, Kazuo Tanaka, Yuji Aiba, Tadahiko Shiba, Atsushi Takagi et al.

Other Journal of gastroenterology and hepatology 2003 77 उद्धरण

<\/script>\n

`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'pmid\u003D12859730'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Study Design

अध्ययन प्रकार: Controlled Clinical Trial
जनसंख्या: CAM-resistant H. pylori-infected patients
अवधि: 8 weeks

हस्तक्षेप: Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection. L. gasseri OLL2716 yogurt
तुलनित्र: CAM-resistant H. pylori patients
प्राथमिक परिणाम: H. pylori suppression
प्रभाव की दिशा: Positive
पूर्वाग्रह का जोखिम: Moderate

Abstract

BACKGROUNDS AND AIM: Clarithromycin (CAM)-resistant Helicobacter pylori sometimes offers serious problems with eradication by antibiotics. The aim of this study was to determine whether a probiotic can be an alternative therapy in CAM-resistant Hp infection. METHODS: The effects of Lactobacillus gasseri (strain OLL2716) on the growth of CAM-susceptible and CAM-resistant H. pylori and interleukin (IL)-8 production provoked by these strains were examined by in vitro experiments. Moreover, mice were infected with these CAM-susceptible or CAM-resistant H. pylori, and were treated with CAM or L. gasseri. RESULTS: In vitro experiments demonstrated that L. gasseri inhibited the growth of H. pylori and suppressed H. pylori-associated IL-8 production. Such effects were noted in CAM-resistant and CAM-susceptible H. pylori. Similarly, in an in vivo model of H. pylori infection, H. pylori colonization was significantly decreased by L. gasseri. CONCLUSION: Therefore, L. gasseri was found to act as a probiotic in CAM-resistant H. pylori infection.

संक्षेप में

The aim of this study was to determine whether a probiotic can be an alternative therapy in CAM‐resistant Hp infection.

Used In Evidence Reviews

B Lactobacillus gasseri के लिए Helicobacter pylori Infection

D Lactobacillus gasseri के लिए Gastroesophageal Reflux Disease (GERD)

Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection.

Embed This Widget

Study Design

Abstract

संक्षेप में

Used In Evidence Reviews

Similar Papers

Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans.

Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health.

The effect of probiotics supplementation on Helicobacter pylori eradication rates and side effects during eradication therapy: a meta-analysis.

Oral administration of lactobacilli from human intestinal tract protects mice against influenza virus infection.

Probiotic and technological properties of Lactobacillus spp. strains from the human stomach in the search for potential candidates against gastric microbial dysbiosis.

Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy.