Alpha-Galactosidase para Irritable Bowel Syndrome (IBS)

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

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Conclusión

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

Key Study Findings

Review

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.

Dose: None vs: None Outcome: None Efecto: None None

Población: None

Randomized Controlled Trial Double-blind

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …

Dose: 1200 G vs: placebo Outcome: every 30 min during 7 Efecto: None None

Población: patients with ibs after three standardized

Randomized Controlled Trial n=31 2.0 weeks Double-blind

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.

Dose: 300 GALU or 150 GALU vs: Placebo (glucose) Outcome: GI symptom severity on VAS Efecto: None pP0.006

Población: IBS patients (Rome III, H2 producers)

Randomized Controlled Trial n=125 4 weeks Double-blind

Does oral α-galactosidase relieve irritable bowel symptoms?

Dose: alpha-galactosidase 600 GalU per meal vs: placebo Outcome: overall IBS symptom relief Efecto: no significant difference vs placebo >0.05

Población: IBS patients

Key Statistics

Estudios

Participantes

↑

Positive

Calificación

Referenced Papers

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. Review

International journal of … 2021 16 citas

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … RCT

Neurogastroenterology and motility 2021 4 citas

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. RCT

The American journal … 2018 49 citas

Does oral α-galactosidase relieve irritable bowel symptoms? RCT

Scandinavian journal of … 2016 17 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods
standardbeanodose:: 300 GalU (2-3 tablets) with first bite of problem food

Límite superior: No established upper limit; adjust per meal as needed

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Mixed	--
1200 G	--	Neutral	--
300 GALU or 150 GALU	2.0 weeks	Positive	31
alpha-galactosidase 600 GalU per meal	4 weeks	Neutral	125

Mejor momento para tomar: With the first bite of gas-producing food

Safety & Side Effects

Efectos secundarios reportados

⚠ Generally very well-tolerated
⚠ Rare allergic reactions to mold-derived enzyme (Aspergillus source)
⚠ May cause mild GI discomfort in rare cases

Interacciones conocidas

● Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
● Miglitol (similar mechanism conflict as acarbose)

Ingesta máxima tolerable: No established upper limit; adjust per meal as needed

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Alpha-Galactosidase help with Irritable Bowel Syndrome (IBS)?

Based on 1 studies with 60 participants, there is preliminary evidence that needs more research that Alpha-Galactosidase may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).

How much Alpha-Galactosidase should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Galactosidase?

Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Galactosidase and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 60 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

Alpha-Galactosidase para otras condiciones

Bloating and Intestinal Gas B

Veredicto rápido

Single study in IBS patients consuming high-FODMAP diet. May reduce gas-related symptoms from specific food triggers.

Evidence Strength30%

Low confidence

Desglose de estudios

RCT (3)Meta (0)Other (0)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Irritable Bowel Syndrome (IBS)

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.