Saccharomyces boulardii لـ Traveler's Diarrhea
BRCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'gutcited.com';
const params = 'ingredient\u003Dsaccharomyces\u002Dboulardii\u0026condition\u003Dtravelers\u002Ddiarrhea';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
B
الخلاصة
RCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.
Key Study Findings
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
مقابل: placebo
Outcome: improvement in key IBS symptoms
التأثير: None
None
المجتمع المدروس: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Randomized Controlled Trial
n=47
8 weeks
Double-blind
Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and …
Dose: None
مقابل: Placebo (Group I) and partial formulation (Group II)
Outcome: IBS quality of life (QoL questionnaire)
التأثير: Dysphoria: median diff -5 (Group III) vs -1 (contr
0.0021 (dysphoria Group III)
المجتمع المدروس: Patients with IBS
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
مقابل: None
Outcome: Clinical guideline recommendations for pediatric GI
التأثير: None
None
المجتمع المدروس: Pediatric patients with GI disorders
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
مقابل: None
Outcome: Probiotic prescribing habits of Italian PCPs
التأثير: L. rhamnosus GG used by 91.8%
None
المجتمع المدروس: Italian primary care pediatricians
Other
n=70
16 weeks
Open-label
Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study.
Dose: None
مقابل: None (single-arm study)
Outcome: Constipation scoring system change
التأثير: -5.3 (95% CI -5.9/-4.7)
0.001
المجتمع المدروس: Peritoneal dialysis patients with chronic constipation
Review
An update on probiotics in paediatrics.
Dose: None
مقابل: None
Outcome: GI disorder outcomes in paediatrics
التأثير: None
None
المجتمع المدروس: Paediatric patients with GI disorders
Key Statistics
4
الدراسات
3200
المشاركون
↑
Positive
B
التقييم
Referenced Papers
Journal of clinical …
2026
Probiotics and antimicrobial …
2025
26 اقتباسات
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 اقتباسات
Frontiers in cellular …
2025
3 اقتباسات
Frontiers in nutrition
2025
3 اقتباسات
Journal of renal …
2025
Antibiotics (Basel, Switzerland)
2025
Boletin medico del …
2025
Current opinion in …
2025
Open forum infectious …
2024
7 اقتباسات
Zhongguo dang dai …
2024
5 اقتباسات
Advances in experimental …
2024
2 اقتباسات
Therapeutic advances in …
2023
97 اقتباسات
Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children.
Systematic Review
Frontiers in pharmacology
2023
20 اقتباسات
Cureus
2023
19 اقتباسات
Cureus
2023
5 اقتباسات
The Journal of …
2023
1 اقتباسات
Archivos argentinos de …
2022
23 اقتباسات
Physiology & behavior
2021
35 اقتباسات
Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections.
Review
World journal of …
2019
92 اقتباسات
Probiotics and antimicrobial …
2019
43 اقتباسات
Applied microbiology and …
2019
25 اقتباسات
Advances in experimental …
2019
17 اقتباسات
Frontiers in medicine
2018
450 اقتباسات
Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.
Systematic Review
PloS one
2018
205 اقتباسات
Pharmacological research
2018
132 اقتباسات
PloS one
2018
76 اقتباسات
World journal of …
2018
52 اقتباسات
The American journal …
2018
46 اقتباسات
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders.
Review
British journal of …
2017
145 اقتباسات
European journal of …
2017
93 اقتباسات
World journal of …
2017
68 اقتباسات
Pediatric gastroenterology, hepatology …
2017
42 اقتباسات
Journal of pediatric …
2016
233 اقتباسات
Clinical and experimental …
2016
82 اقتباسات
Open forum infectious …
2016
58 اقتباسات
Digestive diseases (Basel, …
2016
37 اقتباسات
The Cochrane database …
2015
233 اقتباسات
Antibiotics (Basel, Switzerland)
2015
104 اقتباسات
Journal of clinical …
2015
35 اقتباسات
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 اقتباسات
Nutricion hospitalaria
2015
5 اقتباسات
MMW Fortschritte der …
2014
14 اقتباسات
MMW Fortschritte der …
2014
3 اقتباسات
Expert opinion on …
2014
Frontiers in immunology
2013
263 اقتباسات
The American journal …
2012
104 اقتباسات
Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use.
Other
The American journal …
2012
5 اقتباسات
Medycyna wieku rozwojowego
2012
1 اقتباسات
Journal of clinical …
2011
432 اقتباسات
World journal of …
2010
512 اقتباسات
Digestive diseases and …
2010
45 اقتباسات
Journal for specialists …
2010
22 اقتباسات
Probiotics.
Review
American journal of …
2010
European journal of …
2009
91 اقتباسات
Current opinion in …
2009
82 اقتباسات
Advances in biochemical …
2008
535 اقتباسات
Probiotics.
Review
American family physician
2008
Journal of clinical …
2008
The Journal of …
2007
265 اقتباسات
Nutrition (Burbank, Los …
2007
39 اقتباسات
The Cochrane database …
2007
The American journal …
2006
918 اقتباسات
Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials.
Meta-Analysis
CMAJ : Canadian …
2006
197 اقتباسات
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 اقتباسات
Medical science monitor …
2006
The American journal …
2001
648 اقتباسات
International journal of …
2000
181 اقتباسات
Clinical infectious diseases …
1998
346 اقتباسات
Anaerobe
1997
40 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 250-500 mg/day (equivalent to 5-10 billion CFU)
- aadprevention:
- 500 mg/day (start with antibiotic, continue 7 days after)
- cdiffprevention:
- 500 mg twice daily as adjunct to standard therapy
- travelersdiarrhea:
- 250-500 mg/day starting 5 days before travel
الحد الأعلى: Well-tolerated up to 1,000 mg/day in clinical trials
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| None | 8 weeks | Positive | 47 |
| None | -- | Positive | -- |
| None | -- | Mixed | 279 |
| None | 16 weeks | Positive | 70 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
أفضل وقت للتناول: Can be taken with or without food; space 2 hours from antifungals
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Mild gas and bloating
- ⚠ Rare: fungemia in critically ill patients with central venous catheters
- ⚠ Thirst (yeast may increase water requirements)
- ⚠ Very rare: potential environmental contamination risk in ICU settings
التفاعلات المعروفة
- ● Antifungal medications (may kill S. boulardii, reducing effectiveness)
- ● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
- ● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)
الحد الأقصى المسموح به: Well-tolerated up to 1,000 mg/day in clinical trials
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Saccharomyces boulardii help with Traveler's Diarrhea?
Based on 4 studies with 3,200 participants, there is moderate evidence from clinical studies that Saccharomyces boulardii may support Traveler's Diarrhea management. Our evidence grade is B (Good Evidence).
How much Saccharomyces boulardii should I take for Traveler's Diarrhea?
Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saccharomyces boulardii?
Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saccharomyces boulardii and Traveler's Diarrhea?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 3,200 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Traveler's Diarrhea
Saccharomyces boulardii لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.