Lactobacillus gasseri for Helicobacter pylori Infection
BThree RCTs show L. gasseri LG21 suppresses H. pylori load and improves eradication rates when combined with standard triple therapy. Also improves GERD symptoms.
The Bottom Line
Three RCTs show L. gasseri LG21 suppresses H. pylori load and improves eradication rates when combined with standard triple therapy. Also improves GERD symptoms.
Key Study Findings
Population: AGS gastric epithelial cells and mouse model
Population: Human gastric AGS cell line with H. pylori CagA
Population: None
Population: Cancer patients
Population: H. pylori-infected C57BL/6 mice
Population: Gastric intestinal metaplasia cases and matched controls
Key Statistics
3
Studies
350
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 1-10 billion CFU/day
- gerdsupport:
- 1-5 billion CFU/day
- hpylorisupport:
- 100 million CFU/day (LG21 strain, yogurt form) for 8-12 weeks
Upper limit: Well-tolerated up to 10 billion CFU/day in clinical trials
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 50 μg/ml | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | 178 |
| None | -- | Positive | -- |
| 1 g | -- | Positive | -- |
Best taken: Before meals or with meals; yogurt form taken with food
Safety & Side Effects
Reported Side Effects
- ⚠ Mild gas during initial use
- ⚠ Occasional loose stools
- ⚠ Rare abdominal discomfort
- ⚠ Very rare: bacteremia in immunocompromised individuals
Known Interactions
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Proton pump inhibitors (altered gastric pH may affect colonization)
- ● Immunosuppressants (theoretical risk in immunocompromised patients)
Tolerable upper intake: Well-tolerated up to 10 billion CFU/day in clinical trials
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Lactobacillus gasseri help with Helicobacter pylori Infection?
How much Lactobacillus gasseri should I take for Helicobacter pylori Infection?
Are there side effects of Lactobacillus gasseri?
How strong is the evidence for Lactobacillus gasseri and Helicobacter pylori Infection?
Related Evidence
Other ingredients for Helicobacter pylori Infection
Lactobacillus gasseri for other conditions
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.