Curcumin cho Crohn's Disease
CLimited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'gutcited.com';
const params = 'ingredient\u003Dcurcumin\u0026condition\u003Dibd\u002Dcrohns\u002Ddisease';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
C
Kết luận
Limited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
Key Study Findings
Meta-Analysis
n=2260
Comparative Efficacy of Medical Therapies in Reducing the Risk of Postoperative Recurrence in Crohn's Disease: …
Dose: None
so với: placebo or other medical therapies
Outcome: endoscopic recurrence (Rutgeerts score >= i2) at 6 …
Hiệu quả: adalimumab vs thiopurines OR 0.33 (95% CI 0.12-0.91); adalimumab vs vitamin D OR 0.07 (95% CI 0.01-0
None
Đối tượng nghiên cứu: patients with Crohn's disease post-surgery from 42 studies (38 RCTs)
Meta-Analysis
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of …
Dose: Varying dosages
so với: Placebo
Outcome: Clinical remission and response in UC
Hiệu quả: None
None
Đối tượng nghiên cứu: UC and CD patients (13 RCTs)
Systematic Review
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Dose: Peppermint oil, STW-5, psyllium, others
so với: Standard care or placebo
Outcome: Symptom improvement in GI diseases
Hiệu quả: None
None
Đối tượng nghiên cứu: Patients with gastroenterological diseases
Review
Use of curcumin and its nanopreparations in the treatment of inflammatory bowel disease.
Dose: Curcumin nanoformulations
so với: None
Outcome: IBD symptom improvement
Hiệu quả: None
None
Đối tượng nghiên cứu: IBD patients (preclinical/clinical review)
Review
Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and …
Dose: Various phytochemicals
so với: None
Outcome: NF-kB regulation in IBD
Hiệu quả: None
None
Đối tượng nghiên cứu: In vitro and in vivo IBD models
Meta-Analysis
Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A …
Dose: None
so với: Placebo or standard care
Outcome: Clinical/laboratory outcomes in autoimmune diseases
Hiệu quả: None
None
Đối tượng nghiên cứu: Patients with 10 types of autoimmune diseases
Key Statistics
3
Nghiên cứu
200
Người tham gia
↔
Mixed
C
Xếp hạng
Referenced Papers
Inflammatory bowel diseases
2026
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 trích dẫn
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 trích dẫn
World journal of …
2024
Metabolites
2023
134 trích dẫn
Frontiers in immunology
2022
68 trích dẫn
Molecules (Basel, Switzerland)
2021
85 trích dẫn
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 trích dẫn
United European gastroenterology …
2021
41 trích dẫn
European journal of …
2021
40 trích dẫn
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 trích dẫn
Journal of Crohn's …
2020
71 trích dẫn
Clinical gastroenterology and …
2020
49 trích dẫn
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 trích dẫn
Nutrients
2020
30 trích dẫn
Digestive and liver …
2020
14 trích dẫn
Medicine
2020
4 trích dẫn
International journal of …
2019
137 trích dẫn
Critical reviews in …
2019
48 trích dẫn
Journal of medicinal …
2019
17 trích dẫn
Current opinion in …
2019
5 trích dẫn
Gastroenterology clinics of …
2018
67 trích dẫn
Macromolecular bioscience
2018
13 trích dẫn
Gastroenterology
2017
335 trích dẫn
Medical principles and …
2017
45 trích dẫn
JPEN. Journal of …
2017
24 trích dẫn
Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review.
Systematic Review
Complementary therapies in …
2017
23 trích dẫn
The Medical clinics …
2017
9 trích dẫn
Ugeskrift for laeger
2017
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 trích dẫn
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 trích dẫn
Annals of gastroenterology
2015
135 trích dẫn
Molecules (Basel, Switzerland)
2014
122 trích dẫn
Experimental cell research
2014
16 trích dẫn
The AAPS journal
2013
1866 trích dẫn
Alimentary pharmacology & …
2013
128 trích dẫn
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 trích dẫn
Nature reviews. Gastroenterology …
2013
47 trích dẫn
Food & function
2012
151 trích dẫn
Journal of the …
2009
24 trích dẫn
Molecular nutrition & …
2008
67 trích dẫn
Revista de gastroenterologia …
2008
2 trích dẫn
Digestive diseases and …
2005
461 trích dẫn
Bioinformatics (Oxford, England)
2004
149 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
Giới hạn trên: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Positive | 2260 |
| Varying dosages | -- | Positive | -- |
| Peppermint oil, STW-5, psyllium, others | -- | Positive | -- |
| Curcumin nanoformulations | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Thời điểm dùng tốt nhất: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
Tương tác đã biết
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
Mức hấp thụ tối đa cho phép: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Curcumin help with Crohn's Disease?
Based on 3 studies with 200 participants, there is limited but promising evidence that Curcumin may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Curcumin should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is mixed.
Related Evidence
Các thành phần khác cho Crohn's Disease
Curcumin cho các tình trạng khác
Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.