Saccharomyces boulardii para Traveler's Diarrhea
BRCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.
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B
Conclusão
RCTs show 25-40% reduction in traveler's diarrhea when started 5 days before travel. Effects vary by destination.
Key Study Findings
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: placebo
Outcome: improvement in key IBS symptoms
Efeito: None
None
População: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Randomized Controlled Trial
n=47
8 weeks
Double-blind
Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and …
Dose: None
vs: Placebo (Group I) and partial formulation (Group II)
Outcome: IBS quality of life (QoL questionnaire)
Efeito: Dysphoria: median diff -5 (Group III) vs -1 (contr
0.0021 (dysphoria Group III)
População: Patients with IBS
Other
Ibero-Latin American clinical practice guideline for the use of biotics in pediatric gastroenterology, hepatology, and …
Dose: None
vs: None
Outcome: Clinical guideline recommendations for pediatric GI
Efeito: None
None
População: Pediatric patients with GI disorders
Observational Study
n=279
Use of Probiotics During Antibiotic Therapy in Pediatrics: A Cross-Sectional Survey of Italian Primary Care …
Dose: None
vs: None
Outcome: Probiotic prescribing habits of Italian PCPs
Efeito: L. rhamnosus GG used by 91.8%
None
População: Italian primary care pediatricians
Other
n=70
16 weeks
Open-label
Synbiotic Supplementation for Chronic Constipation in Patients Under Peritoneal Dialysis: An Italian Multicenter Prospective Study.
Dose: None
vs: None (single-arm study)
Outcome: Constipation scoring system change
Efeito: -5.3 (95% CI -5.9/-4.7)
0.001
População: Peritoneal dialysis patients with chronic constipation
Review
An update on probiotics in paediatrics.
Dose: None
vs: None
Outcome: GI disorder outcomes in paediatrics
Efeito: None
None
População: Paediatric patients with GI disorders
Key Statistics
4
Estudos
3200
Participantes
↑
Positive
B
Nota
Referenced Papers
Journal of clinical …
2026
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2025
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The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
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Journal of gastroenterology …
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Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children.
Systematic Review
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2023
20 citações
Cureus
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19 citações
Cureus
2023
5 citações
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2023
1 citações
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2022
23 citações
Physiology & behavior
2021
35 citações
Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections.
Review
World journal of …
2019
92 citações
Probiotics and antimicrobial …
2019
43 citações
Applied microbiology and …
2019
25 citações
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2019
17 citações
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2018
450 citações
Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.
Systematic Review
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2018
205 citações
Pharmacological research
2018
132 citações
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2018
76 citações
World journal of …
2018
52 citações
The American journal …
2018
46 citações
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders.
Review
British journal of …
2017
145 citações
European journal of …
2017
93 citações
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68 citações
Pediatric gastroenterology, hepatology …
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42 citações
Journal of pediatric …
2016
233 citações
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82 citações
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2016
58 citações
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2016
37 citações
The Cochrane database …
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233 citações
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2015
104 citações
Journal of clinical …
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35 citações
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Review
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2015
31 citações
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2015
5 citações
MMW Fortschritte der …
2014
14 citações
MMW Fortschritte der …
2014
3 citações
Expert opinion on …
2014
Frontiers in immunology
2013
263 citações
The American journal …
2012
104 citações
Saccharomyces boulardii and antibiotic-associated diarrhea: effectiveness of prophylactic use.
Other
The American journal …
2012
5 citações
Medycyna wieku rozwojowego
2012
1 citações
Journal of clinical …
2011
432 citações
World journal of …
2010
512 citações
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2010
45 citações
Journal for specialists …
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22 citações
Probiotics.
Review
American journal of …
2010
European journal of …
2009
91 citações
Current opinion in …
2009
82 citações
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2008
535 citações
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Review
American family physician
2008
Journal of clinical …
2008
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2007
265 citações
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39 citações
The Cochrane database …
2007
The American journal …
2006
918 citações
Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials.
Meta-Analysis
CMAJ : Canadian …
2006
197 citações
Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile diarrhea.
Review
Journal of clinical …
2006
112 citações
Medical science monitor …
2006
The American journal …
2001
648 citações
International journal of …
2000
181 citações
Clinical infectious diseases …
1998
346 citações
Anaerobe
1997
40 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 250-500 mg/day (equivalent to 5-10 billion CFU)
- aadprevention:
- 500 mg/day (start with antibiotic, continue 7 days after)
- cdiffprevention:
- 500 mg twice daily as adjunct to standard therapy
- travelersdiarrhea:
- 250-500 mg/day starting 5 days before travel
Limite superior: Well-tolerated up to 1,000 mg/day in clinical trials
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | 8 weeks | Positive | 47 |
| None | -- | Positive | -- |
| None | -- | Mixed | 279 |
| None | 16 weeks | Positive | 70 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
Melhor horário: Can be taken with or without food; space 2 hours from antifungals
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Mild gas and bloating
- ⚠ Rare: fungemia in critically ill patients with central venous catheters
- ⚠ Thirst (yeast may increase water requirements)
- ⚠ Very rare: potential environmental contamination risk in ICU settings
Interações Conhecidas
- ● Antifungal medications (may kill S. boulardii, reducing effectiveness)
- ● Monoamine oxidase inhibitors (S. boulardii contains tyramine)
- ● Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)
Ingestão máxima tolerável: Well-tolerated up to 1,000 mg/day in clinical trials
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Saccharomyces boulardii help with Traveler's Diarrhea?
Based on 4 studies with 3,200 participants, there is moderate evidence from clinical studies that Saccharomyces boulardii may support Traveler's Diarrhea management. Our evidence grade is B (Good Evidence).
How much Saccharomyces boulardii should I take for Traveler's Diarrhea?
Studies have used various dosages. A commonly studied range is 250-500 mg/day (equivalent to 5-10 billion CFU). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saccharomyces boulardii?
Reported side effects may include Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saccharomyces boulardii and Traveler's Diarrhea?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 3,200 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Traveler's Diarrhea
Saccharomyces boulardii para outras condições
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.