Curcumin therapy in inflammatory bowel disease: a pilot study.

Peter R Holt, Seymour Katz, Robert Kirshoff

Other Digestive diseases and sciences 2005 461 citations

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Study Design

Study Type: Controlled Clinical Trial
Sample Size: 10
Population: 5 ulcerative proctitis and 5 Crohn's disease patients

Intervention: Curcumin therapy in inflammatory bowel disease: a pilot study. Curcumin (pure preparation)
Comparator: None
Primary Outcome: Clinical improvement in UC proctitis and Crohn's
Effect Direction: Positive
Risk of Bias: High

Abstract

Curcumin, a natural compound used as a food additive, has been shown to have anti-inflammatory and antioxidant properties in cell culture and animal studies. A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates. This encouraging pilot study suggests the need for double-blind placebo-controlled follow-up studies.

TL;DR

All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates, which suggests the need for double-blind placebo-controlled follow-up studies.

Used In Evidence Reviews

C Curcumin for Crohn's Disease

Curcumin therapy in inflammatory bowel disease: a pilot study.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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