The interaction between obesity and visceral hypersensitivity.

Wu Yanping, Xuefen Gao, Yizun Cheng, Mi Liu, Siyu Liao et al.

Review Journal of gastroenterology and hepatology 2023 16 인용

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Study Design

연구 유형: Review
대상 집단: None

중재: The interaction between obesity and visceral hypersensitivity. None
대조군: None
일차 결과: inflammation markers
효과 방향: Mixed
비뚤림 위험: Unclear

Abstract

Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain-gut axis may be another bridge from obesity to visceral hypersensitivity.

요약

This work has suggested that brain‐gut axis may be another bridge from obesity to visceral hypersensitivity, and obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon.

The interaction between obesity and visceral hypersensitivity.

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Study Design

Abstract

요약

Used In Evidence Reviews

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