**Figure 2.** Figure 2 Approach to 25(OH)D supplementation in patients with IBD. Determining adequate daily dose as (target s-25(OH)D level – current s-25(OH)D level) µg. If target level is not reached within 3 months, administration as weekly bolus should be tried. If current level continues <target level, malabsorption should be considered. CRP, C reactive protein; HBI, Harvey Bradshaw Index; IBD, inflammatory bowel disease; UCDAI, Ulcerative Colitis Disease Activity Index.

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Clinical algorithm for vitamin D supplementation in IBD patients, showing dose calculation based on target 25(OH)D levels, escalation to weekly bolus if targets are unmet, and malabsorption workup considerations.

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Epithelial mechanisms of vitamin D in IBD, illustrating VDR-mediated NF-kB suppression, claudin-2 regulation at the paracellular barrier, and other pathways through which vitamin D influences intestinal inflammation.

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Managing vitamin D deficiency in inflammatory bowel disease.

Frontline gastroenterology (2019)

PMID: 31656565

DOI: 10.1136/flgastro-2018-101055

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![Figure 2: Clinical algorithm for vitamin D supplementation in IBD patients, showing dose calculation based on target 25(OH)D levels, escalation to weekly bolus if targets are unmet, and malabsorption workup considerations.](https://pdfs.citedhealth.com/figures/31656565/105.png)

> Source: Ole Haagen Nielsen et al. "Managing vitamin D deficiency in inflammatory bowel disease.." *Frontline gastroenterology*, 2019. PMID: [31656565](https://pubmed.ncbi.nlm.nih.gov/31656565/)

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  <img src="https://pdfs.citedhealth.com/figures/31656565/105.png" alt="Clinical algorithm for vitamin D supplementation in IBD patients, showing dose calculation based on target 25(OH)D levels, escalation to weekly bolus if targets are unmet, and malabsorption workup considerations." />
  <figcaption>Figure 2. Clinical algorithm for vitamin D supplementation in IBD patients, showing dose calculation based on target 25(OH)D levels, escalation to weekly bolus if targets are unmet, and malabsorption workup considerations.<br>  Source: Ole Haagen Nielsen et al. "Managing vitamin D deficiency in inflammatory bowel disease.." <em>Frontline gastroenterology</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31656565/">31656565</a></figcaption>
</figure>

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