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GutCited

Vitamin D
Vitamin D

vitamin

別名: Cholecalciferol, Vitamin D3, Ergocalciferol, Calciferol

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About





            

                
Vitamin D plays an important role in intestinal health by binding to VDR receptors on intestinal epithelial cells, which may help enhance tight junction protein expression and support the mucosal immune response. Deficiency is common in IBD patients (up to 60%) and correlates with disease activity. Research suggests vitamin D supplementation may help reduce relapse risk in both ulcerative colitis and Crohn's disease, and support overall intestinal barrier integrity.

            

        

        

        
        
        

            

  
How It Works





            

                
Binds VDR receptors on intestinal epithelial cells enhancing tight junction protein expression (claudin-2, -12, -15); modulates mucosal immune response via regulatory T cell differentiation; induces cathelicidin antimicrobial peptide production in intestinal macrophages; deficiency associated with IBD relapse and increased intestinal permeability.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                症状・状態
                                グレード
                                研究数
                                参加者数
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Inflammatory Bowel Disease (IBD) — General
                                    
                                
                                
                                    B

                                
                                
                                    10
                                
                                
                                    1500
                                
                                
                                    
                                        詳細を見る →
                                    
                                
                            

                            
                            

                                
                                    
                                        Irritable Bowel Syndrome (IBS)
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    400
                                
                                
                                    
                                        詳細を見る →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
                
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                    Kidney stones with excessive long-term supplementation
                
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                    Constipation
                
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                    Metallic taste
                
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Drug & Supplement Interactions





            
    
                
                
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                    Thiazide diuretics (may increase risk of hypercalcemia)
                
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                    Corticosteroids (reduce vitamin D absorption and metabolism)
                
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                    Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
                
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                    Statins (vitamin D may affect statin metabolism)
                
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Related Ingredients





            

                
                
                    Vitamin A
                    
                
                
            

        

        
    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。