What is the recommended dosage for Lactobacillus plantarum?

General: 10-20 billion CFU/day; Ibs Support: 10 billion CFU/day (299v strain) for 4 weeks minimum

What are the side effects of Lactobacillus plantarum?

Potential side effects include: Mild gas and bloating during initial use, Occasional loose stools, Histamine-related symptoms in sensitive individuals (histamine-producing species), Very rare: bacteremia in immunocompromised individuals.

What is Lactobacillus plantarum and how does it work for gut health?

Lactobacillus plantarum is a versatile probiotic found in fermented foods like sauerkraut, kimchi, and sourdough. It has a remarkable ability to survive stomach acid and bile, and produces antimicrobial substances that inhibit pathogens. Research suggests it may help reduce bloating, improve intestinal barrier function, and modulate immune responses, with particular evidence for IBS symptom relief.

What is the recommended dosage of Lactobacillus plantarum?

Studies have used dosages of 1 billion to 20 billion CFU per day. The strain L. plantarum 299v (LP299V) is the most clinically studied for IBS, typically at 10-20 billion CFU daily. It is available in both refrigerated and shelf-stable formulations, and can be taken with or without food.

Are there side effects or interactions with Lactobacillus plantarum?

L. plantarum is considered safe with a long history of use in traditional fermented foods. Side effects are rare and mild, typically limited to transient bloating. It has been well-tolerated in clinical trials even at high doses. No significant drug interactions have been reported, and it is one of the probiotic species with the broadest safety data.

Lactobacillus plantarum
Lactobacillus plantarum

probiotic_strain

別名: L. plantarum, Lactiplantibacillus plantarum, 299v, WCFS1

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About

Lactobacillus plantarum is a versatile probiotic species with strong adhesion to the intestinal mucosa, allowing it to effectively compete with pathogens for binding sites. It produces plantaricin, a natural antimicrobial peptide, and may help modulate NF-kB inflammatory signaling in the gut. The 299v strain has been particularly well-studied for supporting digestive comfort in IBS.

How It Works

Adheres strongly to intestinal mucosa competing with pathogens for binding sites; produces plantaricin antimicrobial peptides with broad-spectrum activity; modulates NF-kB inflammatory signaling reducing pro-inflammatory cytokine production; enhances short-chain fatty acid production in the colon.

Evidence For Conditions

症状・状態	グレード	研究数	参加者数
Irritable Bowel Syndrome (IBS)	B	5	800	詳細を見る →

Side Effects

Mild gas and bloating during initial use
Occasional loose stools
Histamine-related symptoms in sensitive individuals (histamine-producing species)
Very rare: bacteremia in immunocompromised individuals

Drug & Supplement Interactions

Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
Immunosuppressants (theoretical risk in immunocompromised patients)
Histamine-intolerance medications (L. plantarum may produce biogenic amines)

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Related Ingredients

Bifidobacterium longum Bifidobacterium bifidum Lactobacillus gasseri Lactobacillus casei Bifidobacterium lactis

基本情報

用量: General: 10-20 billion CFU/day; Ibs_Support: 10 billion CFU/day (299v strain) for 4 weeks minimum
剤形: capsule powder sachet fermented foods
天然の供給源: Sauerkraut, Kimchi, Pickled vegetables, Sourdough bread, Olives
上限量: Well-tolerated up to 20 billion CFU/day in clinical trials
推奨摂取タイミング: On an empty stomach or before meals

エビデンスの要約

Irritable Bowel Syndrome (IBS) B

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。